慢性伤口治疗中普遍存在的问题？

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蔡道章院长

Custom Mod Mega1

主任医师、教授、博导，南方医科大学第三附属医院（广东省骨科医院）院长

中德骨科伤口管理学校校长

广东省骨科研究院运动医学研究所所长

广东省内运动医学专业唯一的博士研究生导师

美国哈弗大学医学院骨科访问学者

专业特长处于省内领先、国内或国际先进水平以上

2018年获得“国之名医卓越建树”荣誉称号

2017年被评为全国卫生计生系统先进工作者、广东省医学领军人才

中国医师协会运动医师分会副会长

STCOT中国部运动医学分会副主任委员

广东省医学会关节外科分会主任委员

广东省医学会运动医学会分会名誉主任委员

独立承担过国家“863”课题，主持过10余项省、部级科研项目

多份专业杂志编委
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最新文献

Small molecule conjugates with selective estrogen receptor b agonism promote anti-aging benefits in metabolism and skin recovery 2025-05-16 00:00

Tarik Zahra,b,y , Vijay K. Bodac,d,y , Jian Gee,f,y , Lexiang Yua,g , Zhongzhi Wuc,d , Jianwen Quee,f,h, *, Wei Lic,d, *, Li Qianga,g, *

a Naomi Berrie Diabetes Center, Columbia University, New York, NY 10032, USA

b Department of Molecular Pharmacology and Therapeutics, Columbia University, New York, NY 10032, USA

c Department of Pharmaceutical Sciences, College of Pharmacy, University of Tennessee Health Science Center, Memphis, TN 38163, USA

d Drug Discovery Center, College of Pharmacy, University of Tennessee Health Science Center, Memphis, TN 38163, USA

e Division of Digestive and Liver Diseases, Columbia University, New York, NY 10032, USA

f Center for Human Development, Columbia University, New York, NY 10027, USA

g Department of Pathology and Cell Biology, Columbia University, New York, NY 10032, USA

h Department of Medicine, Columbia University, New York, NY 10032, USA

*Corresponding authors.

E-mail addresses: 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。 (Jianwen Que), 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。 (Wei Li), 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。 (Li Qiang).

These authors made equal contributions to this work.

Peer review under the responsibility of Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences.

Received 22 October 2023; received in revised form 13 December 2023; accepted 5 January 2024

KEY WORDS Estrogen receptor b; Aging; Metabolism; Skin injury; Muscle metabolism; Small molecule conjugates; Regeneration; Adiposity

Skin anti-aging potential of Launaea procumbens extract: Antioxidant and enzyme inhibition activities supported by ADMET and molecular docking studies 2025-05-15 00:00

Hanan Khojah a , Shaima R. Ahmed a,* , Shahad Y. Alharbi a , Kholood K. AlSabeelah a ,

Hatham Y. Alrayyes a , Kadi B. Almusayyab a , Shahad R. Alrawiliy a , Raghad M. Alshammari a ,

Sumera Qasim b

a Department of Pharmacognosy, College of Pharmacy, Jouf University, Sakaka 72341, Saudi Arabia

b Department of Pharmacology, College of Pharmacy, Jouf University, Sakaka 72341, Saudi Arabia

Corresponding author at: College of Pharmacy, Jouf University, Sakaka 72341, Saudi Arabia.

E-mail address: 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。 (S.R. Ahmed)

ARTICLE INFO

Keywords:

Launaea procumbens

Anti-aging

ADMET

Docking

ABSTRACT

Aging is a natural process that occurs in all living organisms. Particularly, the skin embodies aging since it serves as a barrier between the body and its surroundings. Previously, we reported the wound healing effect of Launaea procumbens and identified compounds therein. The study aims to explore the skin anti-aging properties of the plant extract. To that effect, the antioxidant potential of L. procumbens methanolic extract (LPM) was assessed using two complementary DPPH and FRAP assays. The enzyme inhibitory effect of the extract on collagenase, elastase, hyaluronidase, and tyrosinase was evaluated to assess the direct skin anti-aging effects. Similarly, the anti-inflammatory activity was evaluated to explore the indirect anti-aging effects via the assessment of extract inhibitory effects on cyclooxygenase-2 (COX-2) and 5-lipoxygenase (5-LOX). In addition, ADMET and molecular docking studies were performed to explore the interaction mechanisms of identified compounds in LPM with target enzymes. LPM demonstrated significant antioxidant activity in DPPH (IC50 = 29.08 µg/mL) and FRAP (1214.67 µM FeSO4/g extract) assays. Plant extract showed significant inhibition of collagenase, elastase, hyaluronidase, and tyrosinase (IC50 = 52.68, 43.76, 31.031, and 37.13 µg/mL, respectively). The extract demonstrated significant COX-2 and 5-LOX inhibition capacity with IC50 values of 8.635 and 10.851 µg/mL, respectively. The molecular docking study revealed the high potential of the identified compounds to bind to the active sites of enzymes crucially involved in the skin aging process. ADMET analysis of the compounds revealed their good absorption, distribution, and metabolism profiles, and they were found to be safe as well. Study findings suggest L. procumbens as a promising source for the development of natural skin anti-aging and anti oxidant compounds. This, in turn, may facilitate its incorporation into cosmetic formulations after further investigation.
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慢性伤口治疗中普遍存在的问题？

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12 10月 2019

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Author : 伤口世界

慢性伤口治疗中普遍存在的问题？

原创：卢魁

慢性伤口治疗中普遍是什么问题困扰着患者呢？

问题一：悲观思想，认为患了不治之症
事实上，精神压力和疾病之间，存在着一条明显的纽带。对疾病切勿忧虑恐惧，悲观失望，郁郁寡欢，闷闷不乐，要学会自我克制、自我调节，要心胸宽广，豁达大度，树立战胜疾病的信念，要有毅力和勇气。
问题二:
轻信广告和传言，相信“神药”
慢性伤口是一种长期慢性疾病，其中很多疾病都是没有办法完全根治的，因此必须要有长期和疾病做斗争的思想认识。切勿相信广告所说的秘方、神药，以免上当受骗，耽误病情。
问题三：
为什么症状控制后仍需要长期观察预防复发？
到目前为止，慢性伤口大部分尚不能根治，需要长期治疗让伤口愈合。症状减轻仅意味着病情得到控制，并未完全治愈。体内的病变可能并没有真正停止，停药后或受到外界刺激仍会复发。只有改变生活习惯、合理功能锻炼、合理使用控制病情的药物(慢作用药物)，才能减缓或阻止上述过程的进展。

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学术会议

2019广东省医疗行业协会伤口管理分会年会

扫一扫了解详情:

2019年6月15日中国广州
主办单位：广东省医疗行业协会伤口管理分会

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