慢性伤口治疗中普遍存在的问题？

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主任医师、教授、博导，南方医科大学第三附属医院（广东省骨科医院）院长

中德骨科伤口管理学校校长

广东省骨科研究院运动医学研究所所长

广东省内运动医学专业唯一的博士研究生导师

美国哈弗大学医学院骨科访问学者

专业特长处于省内领先、国内或国际先进水平以上

2018年获得“国之名医卓越建树”荣誉称号

2017年被评为全国卫生计生系统先进工作者、广东省医学领军人才

中国医师协会运动医师分会副会长

STCOT中国部运动医学分会副主任委员

广东省医学会关节外科分会主任委员

广东省医学会运动医学会分会名誉主任委员

独立承担过国家“863”课题，主持过10余项省、部级科研项目

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Electrolyzed hypochlorous acid water exhibits potent disinfectant activity against various viruses through irreversible protein aggregation 2026-09-30 00:00

Rahmi Dianty^1,2 , Junki Hirano^1,2 , Itsuki Anzai^1,3 , Yuta Kanai^1,4 , Tsuyoshi Hayashi⁵ , Masae Morimoto⁶ , Chikako Kataoka-Nakamura⁶ , Sakura Kobayashi⁵ , Kentaro Uemura^1,2 , Chikako Ono^1,2 , Tokiko Watanabe^1,3,7 , Takeshi Kobayashi^1,4,7 , Kosuke Murakami⁵ , Kenji Kikuchi⁸ , Kunimoto Hotta⁸ , Toshikazu Yoshikawa⁸ , Shuhei Taguwa^{1,2,7 *} and Yoshiharu Matsuura^{1,2,7 *}

¹ Laboratory of Virus Control, Center for Infectious Disease Education and Research, Osaka University, Osaka, Japan, 2Laboratory of Virus Control, Research Institute for Microbial Diseases, Osaka University, Osaka, Japan, 3Laboratory of Molecular Virology, Research Institute for Microbial Diseases, Osaka University, Osaka, Japan, 4Laboratory of Virology, Research Institute for Microbial Diseases, Osaka University, Osaka, Japan, 5Department of Virology II, National Institute of Infectious Diseases, Tokyo, Japan, 6Innovative Vaccine Research and Development Center, The Research Foundation for Microbial Diseases of Osaka University, Osaka, Japan, 7 Center for Advanced Modalities and DDS, Osaka University, Osaka, Japan, 8Louis Pasteur Center for Medical Research, Kyoto, Japan

It is essential to employ efficient measures to prevent the transmission of pathogenic agents during a pandemic. One such method involves using hypochlorous acid (HClO) solution. The oxidative properties of HClO water (HAW) can contribute to its ability to eliminate viral particles. Here, we examined a highly purified slightly acidic hypochlorous acid water (Hp-SA-HAW) obtained from the reverse osmosis membrane treatment of an electrolytically-generated SA-HAW for its anti-viral activity and mode of action on viral proteins. Hp-SA-HAW exhibited broad-spectrum antiviral effects against various viruses, including adenovirus, hepatitis B virus, Japanese encephalitis virus (JEV), and rotavirus. Additionally, Hp-SA-HAW treatment dose-dependently resulted in irreversibly aggregated multimers of the JEV envelope and capsid proteins. However, Hp-SA-HAW treatment had no discernible effect on viral RNA, indicating that Hp-SA HAW acts against amino acids rather than nucleic acids. Furthermore, Hp-SA-HAW substantially reduced the infectivity of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), including the ancestral variant and other multiple variants. Hp-SA-HAW treatment induced the aggregation of the SARS-CoV-2 spike and nuclear proteins and disrupted the binding of the purified spike protein of SARS-CoV-2 to human ACE2. This study demonstrates that the broad-spectrum virucidal activity of highly purified HClO is attributed to viral protein aggregation of virion via protein oxidation.

KEYWORDS

hypochlorous acid, virucide, SARS-CoV-2, oxidation, protein aggregation

Hypochlorous acid is antipruritic and anti-inflammatory in a mouse model of atopic dermatitis 2026-09-29 00:00

T. Fukuyama¹ | B. C. Martel¹ | K. E. Linder² | S. Ehling¹ | J. R. Ganchingco¹ | W. B€aumer^1,3

Summary

Background: It has been reported that topical hypochlorous acid (HOCl) formulations lead to relief of itch in human patients with atopic dermatitis; however, the specific antipruritic mechanism of action remains unclear.

Objective: To confirm itch relief and reduction of lesions in a mouse model of atopic dermatitis and to elucidate possible HOCl’s mode of action.

Methods: In this study, the effects of topical administration of HOCl hydrogel (0.05%) on atopic dermatitis-like lesions in NC/Nga mice model as well as in vitro effects of HOCl on dorsal root ganglia neurons and mouse bone marrow-derived dendritic cells (mBMDCs) were investigated. NC/Nga mice were sensitized with house dust mite allergen and treated topically with HOCl hydrogel both preventively and therapeutically against established lesions. Allergen challenge was continued during HOCl hydrogel application.

Results: Treatment with HOCl hydrogel prevented the development of lesions and scratching bouts during the whole observation period. When administered after full development of lesions, HOCl reduced lesions and scratching behaviour to a similar extent as a positive control 0.1% betamethasone dipropionate ointment. The reduced inflammatory response by HOCl treatment was demonstrated by reduced secretion of inflammatory cytokines in affected skin tissue from NC/Nga mice. In addition, HOCl significantly reduced IL-12 production in mBMDC. The diminished scratching behaviour was confirmed by impaired response to several pruritogens in dorsal root ganglia neurons excised from NC/Nga mice after termination of the studies. The response to the stimuli was also reduced by pre-incubation of sensory neurons from untreated BALB/c mice with 0.0001% HOCl. Conclusions and Clinical Relevance: These data indicate a direct reduction in sensory response by HOCl, leading to significantly reduced itch and inflammation in vivo.

KEYWORDS

atopic dermatitis, dorsal root ganglia, hypochlorous acid, IgE, IL-13, IL-4, NC/Nga mice, sensory neurons
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慢性伤口治疗中普遍存在的问题？

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12 10月 2019

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Author : 伤口世界

慢性伤口治疗中普遍存在的问题？

原创：卢魁

慢性伤口治疗中普遍是什么问题困扰着患者呢？

问题一：悲观思想，认为患了不治之症
事实上，精神压力和疾病之间，存在着一条明显的纽带。对疾病切勿忧虑恐惧，悲观失望，郁郁寡欢，闷闷不乐，要学会自我克制、自我调节，要心胸宽广，豁达大度，树立战胜疾病的信念，要有毅力和勇气。
问题二:
轻信广告和传言，相信“神药”
慢性伤口是一种长期慢性疾病，其中很多疾病都是没有办法完全根治的，因此必须要有长期和疾病做斗争的思想认识。切勿相信广告所说的秘方、神药，以免上当受骗，耽误病情。
问题三：
为什么症状控制后仍需要长期观察预防复发？
到目前为止，慢性伤口大部分尚不能根治，需要长期治疗让伤口愈合。症状减轻仅意味着病情得到控制，并未完全治愈。体内的病变可能并没有真正停止，停药后或受到外界刺激仍会复发。只有改变生活习惯、合理功能锻炼、合理使用控制病情的药物(慢作用药物)，才能减缓或阻止上述过程的进展。

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2019广东省医疗行业协会伤口管理分会年会

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2019年6月15日中国广州
主办单位：广东省医疗行业协会伤口管理分会

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