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SagarKiranKhadke ,Jin-HyungLee,Yong-GuyKim,VinitRajandJintaeLee*
School of Chemical Engineering,Yeungnam University,Gyeongsan38541,Korea;该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。(S.K.K.); 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。(J.-H.L.);该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。(Y.-G.K.);该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。(V.R.)">该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。(J.-H.L.);该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。(Y.-G.K.);该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。(V.R.) *Correspondence:该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。;Tel.:+82-53-810-2533;Fax:+82-53-810-4631
Citation: Khadke, S.K.; Lee, J.-H.; Kim, Y.-G.; Raj, V.; Lee, J. Assessment of Antibiofilm Potencies of Nervonic and Oleic Acid against Acinetobacter baumannii Using In Vitro and Computational Approaches. Biomedicines 2021, 9, 1133. https://
doi.org/10.3390/biomedicines9091133
Academic Editor: Leonardo Caputo
Received: 19 July 2021
Accepted: 29 August 2021
Published: 1 September 2021
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Copyright: © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/4.0/).
Abstract: Acinetobacter baumannii is a nosocomial pathogen, and its biofilms are tolerant to desiccation, nutrient starvation, and antimicrobial treatment on biotic and abiotic surfaces, tissues, and medical devices. Biofilm formation by A. baumannii is triggered by a quorum sensing cascade, and we hypothesized that fatty acids might inhibit its biofilm formation by interfering with quorum sensing. Initially, we investigated the antibiofilm activities of 24 fatty acids against A. baumannii ATCC 17978 and two clinical isolates. Among these fatty acids, two unsaturated fatty acids, nervonic and oleic acid, at 20 µg/mL significantly inhibited A. baumannii biofilm formation without affecting its planktonic cell growth (MICs were >500 µg/mL) and markedly decreased the motility of A. baumannii but had no toxic effect on the nematode Caenorhabditis elegans. Interestingly, molecular dynamic simulations showed that both fatty acids bind to the quorum sensing acyl homoserine lactone synthase (AbaI), and decent conformational stabilities of interactions between the fatty acids and AbaI were exhibited. Our results demonstrate that nervonic and oleic acid inhibit biofilm formation by A. baumannii strains and may be used as lead molecules for the control of persistent A. baumannii infections.
Keywords: Acinetobacter baumannii; biofilm formation; AbaI; computational studies; fatty acid; nervonic acid; virulence; quorum sensing; antibiofilm agents.
Tae Kyung Hyun1 and Ju-Sung Kim2*
1Institut fuer Pflanzenwissenschaften, Schubertstr. 51, A-8010 Graz, Austria. 2Oriental Bio-herb Research Institute, Kangwon National University, Chuncheon, 200-701, Korea. Accepted 17 August, 2009
Kalopanax pictus is known as Castor-Aralia or Prickly Castor-oil tree. K. pictus extracts have been used for dietary health supplements and are an important area in drug development with numerous pharmacological functions in East Asia; however, their pharmacological functions have not been introduced in Western countries. This paper briefly reviews the most relevant experimental data on the pharmacological actions of K. pictus to overcome the lack of information on this plant. K. pictus extracts have proved to be effective in the treatment of inflammation and were shown to have a number of pharmaceutically relevant benefits that include anti-rheumatoidal, hepatoprotective, anti-diabetic, anti-cancer effects, etc. There are a few known active pharmacological components such as kalopanaxsaponin A and I. Although the molecular mechanisms of most of the effects are not fully understood, major mechanisms seem to involve the interplay between active components and signaling mediated by phosphorylation events during stress adaptation.
Key words: Kalopanax pictus, araliaceae, Kalopanaxsaponins A, anti-inflammatory, anti-rheumatoidal activity, anti-diabetic, hepatoprotective effect.
Agnese Di Napoli* and Pietro Zucchetti
Abstract
Background: Taraxacum officinale (G.H. Weber ex Wiggers), commonly known as dandelion, is a herbaceous plant native to North America, Europe and Asia. This plant has been used for health purposes since ancient times. The phytochemicals present in different parts of the plant are responsible for its medicinal properties. In this review, we describe the main health properties of Taraxacum officinale.
Main body of the abstract: We searched for the main medicinal properties of Taraxacum officinale in the scientific literature, using the PubMed database. We selected 54 studies and we described twelve therapeutic properties, which are reported in previous studies. These properties are diuretic, hepatoprotective, anticolitis, immunoprotective, antiviral, antifungal, antibacterial, antiarthritic, antidiabetic, antiobesity, antioxidant and anticancer effects. We also found that the most frequently reported therapeutic effects include hepatoprotective, antioxidant and anticancer activities.
Short conclusion: In this review, we describe the medicinal properties of Taraxacum officinale reported in previous studies. Antioxidant, hepatoprotective and anticancer effects are mostly found in the scientific literature.
Keywords: Taraxacum officinale, Dandelion, Medicinal properties, Hepatoprotective, Antioxidant, Anticancer.
David C. Klonoff, M.D., FACP
Author Affiliation: Mills-Peninsula Health Services, San Mateo, California
Abbreviation: (A1C) hemoglobin A1c
Corresponding Author: David C. Klonoff, M.D., FACP, Mills-Peninsula Health Services, 100 South San Mateo Drive, Room 5147, San Mateo, CA 94401; email address 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。 J Diabetes Sci Technol 2009;3(4):624-628
