Ivan Chorbev, Marija Sotirovska, and Dragan Mihajlov

Faculty of Computer Science and Engineering, Ss. Cyril and Methodius University in Skopje, P.O. BOX 574, 1000 Skopje, Macedonia

Correspondence should be addressed to Ivan Chorbev, 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。

Received 31 May 2011; Revised 28 July 2011; Accepted 29 August 2011

Academic Editor: Sotiris A. Pavlopoulos

Copyright © 2011 Ivan Chorbev et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

      Diabetes is classified as the world’s fastest-growing chronic illness that affects millions of people. It is a very serious disease, but the bright side is that it is treatable and can be managed. Proper education in this view is necessary to achieve essential control and prevent the aggregation of this chronic sickness. We have developed a healthcare social network that provides methods for distance learning; opportunities for creation of virtual self-help groups where patients can get information and establish interactions among each other in order to exchange important healthcare-related information; discussion forums; patient-to-healthcare specialist communication. The mission of our virtual community is to increase the independence of people with diabetes, self-management, empower them to take care of themselves, make their everyday activities easier, enrich their medical knowledge, and improve their health condition, make them more productive, and improve their communication with other patients with similar diagnoses. The ultimate goal is to enhance the quality of their life.

Jacquelyn Dawn Parente, Knut Möller

Institute of Technical Medicine, Furtwangen University, Villingen-Schwenningen, Germany

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How to cite this paper: Parente, J.D. and Möller, K. (2017) A Control System Design to Establish Dose-Response Relationships in Wound Healing Therapy. J. Biomedical Science and Engineering, 10, 76-85.

https://doi.org/10.4236/jbise.2017.105B009

Received: April 13, 2017

Accepted: May 3, 2017

Published: May 10, 2017

Abstract

      Advanced biophysical wound healing therapies can apply mechanical, electrical, or light energy to re-stimulate healing processes in chronic wounds. Despite the growing evidence of the clinical efficacy of these therapies, the optimal treatment stimulation parameters remain unknown and there are no standard treatment protocols. We introduce a closed-loop control design as an experimental system to study the dose-response of wound healing therapy treatment within a prescribed multidimensional and multimodal stimulation parameter space. Systems engineering approaches are applied to the control problem for estimation of a transfer function and model equations derived for use in optimal model-based control. The experimental control system design consisted of simultaneous application of biophysical energies inputted into a wound system. A study design set up including the use of negative pressure wound therapy, electrical stimulation therapy, and photobiomodulation device systems was described. Treatment stimulation parameters were selected from experimental ranges used in the scientific literature. Classical control methods and model-based control were suggested for model selection and evaluation and design of the overall control system. An experimental design for multimodal biophysical wound healing therapy control system is introduced to establish the dose-response interactions for development of therapeutic applications and device design.

Keywords

      Chronic wounds, High voltage pulsed current, Low level light therapy, Negative pressure wound therapy, Modeling and control, Photobiomodulation, Wound healing.

Jialiang Chen, Louis Chebli

Department of Vascular Surgery, CHU Brugmann, Brussels, Belgium

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How to cite this paper: Chen, J.L. and Chebli, L. (2021) Case Report of a Chronic Wound Due to Venous Insufficiency Following a Traumatic Arteriovenous Fistula. Open Journal of Clinical Diagnostics, 11,

47-51. https://doi.org/10.4236/ojcd.2021.112003 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。

Received: May 17, 2021

Accepted: June 26, 2021

Published: June 29, 2021

Abstract

      Chronic lower limb wounds are common. They can be of arterial or venous origin. In this article, we will present a clinical case of a 30-year-old patient with a chronic injury to the right medial malleolus. In his history, we can note a gunshot wound to the right leg. Ultrasonography and CT angiography helped in the diagnosis of traumatic arteriovenous fistula. The patient underwent a fistula embolization which allowed the wound to heal. The clinical presentation, additional examinations and the latest treatment recommendations will be discussed in this article.

Keywords

Arteriovenous Fistula, Chronic Wound, Trauma, Venous Insufficiency

Copyright © 2021 by author(s) and Scientific Research Publishing Inc. This work is licensed under the Creative Commons Attribution International License (CC BY 4.0).

http://creativecommons.org/licenses/by/4.0/

Albertine Lapp1 , Pascal Furrer1 , Albert-Adrien Ramelet2 , Christian Aubort3 , Pierre Aubort3 ,Philippe Laurent1,4, Lee Ann Applegate4,5

1Department of Pharmaceutical Sciences, University of Geneva, Geneva, Switzerland;

2 Office of Dermatology and Angiology,Lausanne, Switzerland;

3 Sincopharm, Moudon, Switzerland;

4 Tec-Pharma, Bercher, Switzerland;

5 Department of Plastic and Reconstructive Surgery, University Hospital, Lausanne, Switzerland.

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Received November 15th, 2012; revised December 18th, 2012; accepted December 27th, 2012

ABSTRACT

      Biologicals have been used for decades in biopharmaceutical topical preparations. Because cellular therapies are routinely used in the clinic they have gained significant attention. Different derivatives are possible from different cell and tissue sources, making the selection of cell types and establishment of consistent cell banks crucial steps in the initial whole-cell bioprocessing. Various cell and tissue types have been used in treatment of skin wounds including autologous and allogenic skin cells, platelets, placenta and amniotic extracts from either human or animal sources. Experience with progenitor cells show that they may provide an interesting cell choice due to facility of out-scaling and known properties for wound healing without scar. Using defined animal cell lines to develop cell-free derivatives may provide initial starting material for pharmaceutical formulations that help in overall stability. Cell lines derived from ovine tis sue (skin, muscle, connective tissue) can be developed in short periods of time and consistency of these cell lines was monitored by cellular life-span, protein concentrations, stability and activity. Each cell line had long culture periods up to 37 - 41 passages and protein measures for each cell line at passages 2 - 15 had only 1.4-fold maximal difference. Growth stimulation activity towards two target skin cell lines (GM01717 and CRL-1221; 40 year old human males) at concentrations ranging up to 6 μg/ml showed 2-3-fold (single extracts) and 3-7-fold (co-cultured extracts) increase. Proteins from co-culture remained stable up to 1 year in pharmaceutical preparations shown by separation on SDSPAGE gels. Pharmaceutical cell-free preparations were used for veterinary and human wounds and burns. Cell lines and cell-free extracts can show remarkable consistency and stability for preparation of biopharmaceutical creams, moreover when cells are co-cultured, and have positive effects for tissue repair.

Keywords: Biological; Wound Healing; Scars; Cell-Free Derivatives