伤口世界

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星期四, 17 10月 2019

近100年乳腺癌的外科治疗演变，是医生不懈的努力！

负压引流与创面修复以下文章来源于普外时间，作者萤火虫医生

79 岁的琼瑶于 3 月 12 日在 Facebook 上发的一篇文章（写给儿子和儿媳的一封公开信）引起了热议，大致意思是嘱咐亲人一旦自己患救治希望渺茫的重病，一定不要再全力抢救。

这种观念至今对于很多人来讲仍难以接受。「不能眼睁睁看着他死」、「哪怕有一丝希望，哪怕砸锅卖铁也要去救」「只要还有一口气在，我们就不会放弃治疗」，这些言语医生每天都能听得到。

星期四, 17 10月 2019

安全过年 ll 年关了，价值过万的鱼刺，长啥样？

原创：胡海涛负压引流与创面修复

2018-2-13 20:00 年二十八

医护人员加班，为了一根‘鱼刺’

星期四, 17 10月 2019

从医多年，很多时间在诊治‘腹痛’患者，有一部分患者因为诊治不及时，导致严重并发症，影响一辈子，甚至死亡。我们医生花费了大量的精力和时间，患者花费了大量的费用和承受了巨大的痛苦，结果是医患双方都痛苦，医生和家属的努力都没换到理想的结果！如果早给我们机会，结果可能就不一样了，这是我们医生经常惋惜的感叹。急腹症的处理，时间就是生命！一台手术，一次在有限范围内救治一个患者，一篇科普文章，希望可以帮助更多的朋友！

星期四, 17 10月 2019

患胆结石的母子二人，胆囊切除后的生活质量变化竟然是？

胡海涛负压引流与创面修复

母，54岁，反复右上腹疼痛10年，再发2周，当地医院诊断1.胆囊结石慢性胆囊炎 2.胆总管结石 3.急性胰腺炎，建议开刀手术：胆囊切除+胆总管切开取石，为微创手术就诊我院，先ERCP取胆总管结石时发现胃潴留、十二指肠狭窄，于2016年6月24日行腹腔镜下胆囊切除+胆总管切开取石+一期胆总管缝合+胃大部切除+毕二胃空肠吻合术，术后第9天痊愈出院。

星期四, 17 10月 2019

我们从洗脚开始，1月治愈94岁婆婆两年的烂脚！

胡海涛负压引流与创面修复

简介：霍婆婆，94岁，右足背溃烂2年，曾在多家医院诊治，未愈，2018-3-9就诊我院：

星期四, 17 10月 2019

急诊外科轮转那年的儿童节，用完备用的小手术包！

原创：胡海涛负压引流与创面修复

几年前，急诊科值夜班，17：00接班，刚坐下不久，小儿外伤接踵而至，一直忙到23：00，用完所有小手术包后，才吃晚饭！

K2 Content

异体表皮干细胞对裸鼠全层皮肤缺损创面移植异体全厚皮成活的影响及其机制 2024-11-22 00:00

黄韶斌 1 胡志成 1 张逸 2 唐冰 1 王鹏 1 徐海琳 1 王志勇 1 董云先 1 程璞 1 荣燕超 1 吴军 3 朱家源 1

1 中山大学附属第一医院烧伤科，广州 510080；

2 南通大学附属医院烧伤整形外科 226001；3 深圳大学第一附属医院烧伤整形科 518037 通信作者：朱家源，Email：该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。
Novel Cosmetic Ingredient CS-AA Polyion Complex and Skin Moisturizing Effect 2024-11-20 00:00

Hyungjoon Jeon Yong Won Shin Jong Gu Won Nojin Park Sang-Wook Park Nam Seo Son Mi-Sun Kim

LG Household & Health Care (LG H&H), LG Science Park R&D Center, Seoul, Republic of Korea

Correspondence: Hyungjoon Jeon (该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。) Mi-Sun Kim (该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。)

Received: 29 January 2024

Revised: 21 June 2024

Accepted: 19 July 2024

Keywords: arginine | chondroitin sulfate | glutamine | skin hydration | TEWL | water-holding capacity

ABSTRACT

Purpose: The study explored the enhanced skin moisturizing capabilities and moisture retention effects achieved by forming a polyion complex using sulfated glycosaminoglycan (GAG), specifically chondroitin sulfate (CS), and amino acids (AA) such as glutamine (Q) and arginine (R). The overall hydration effect of this CS-AA complex was examined.

Methods: After analyzing the CS-AA polyion complex structure using spectroscopic methods, the ex vivo moisture retention ability was assessed under dry conditions using porcine skin samples. Additionally, the efficacy of the CS-AA polyion complex in reducing transepidermal water loss (TEWL) and improving skin hydration was evaluated on human subjects using a digital evaporimeter and a corneometer, respectively.

Results: Validating a systematic reduction in particle size, the following order was observed: CS > CS/AA simple mixture > CSAA complex based on dynamic light scattering (DLS) and transmission electron microscopy (TEM) analysis. Furthermore, observations revealed that the CS-AA complex exhibits negligible surface charge. Additionally, Fourier-transform infrared spectroscopy (FT-IR) analysis demonstrated a distinct peak shift in the complex, confirming the successful formation of the CS-AA complex. Subsequently, the water-holding effect through porcine skin was assessed, revealing a notable improvement in moisture retention (weight loss) for the CS-Q complex: 40.6% (1 h), 20.5% (2 h), and 18.7% (4 h) compared to glycerin. Similarly, the CS-R complex demonstrated enhancements of 50.2% (1 h), 37.5% (2 h), and 33% (4 h) compared to glycerin. Furthermore, TEWL improvement efficacy on human skin demonstrated approximately 25% improvement for both the CS-Q complex and CS-R complex, surpassing the modest 12.5% and 18% improvements witnessed with water and glycerin applications, respectively. Finally, employing a corneometer, hydration changes in the skin were monitored over 4 weeks. Although CS alone exhibited nominal alterations, the CS-Q complex and CS-R complex showed a significant increase in moisture levels after 4 weeks of application.

Conclusion: In this study, polyion complexes were successfully formed between CS, a sulfated GAG, and AA. Comparisons with glycerin, a well-known moisturizing agent, confirmed that the CS-AA complex exhibits superior moisturizing effects in various aspects. These findings suggest that the CS-AA complex is a more effective ingredient than CS or AA alone in terms of efficacy.
Comprehensive evaluation of the efficacy and safety of a new multi-component anti-aging topical eye cream 2024-11-19 00:00

Fan Yang1 Xinyuan Zhang2 Hua Wang1 Miao Guo1 Jinlong Zhang1 Xuejiao Feng3 Jiayi Yu3 Jiahui Yang3 Jinjin Zhu4 Yiyu Wang3

1 Research & Development Center, Mageline Biology Tech Co., Ltd, Wuhan, Hubei, China

2 Shanghai Skinshield Clinical Testing and Technological Research Ltd., Shanghai, China

3 Department of Dermatology, Air Force Medical Center, PLA, Beijing, China

4 Department of Dermatology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology (HUST), Wuhan, China

Correspondence

Jinjin Zhu, Department of Dermatology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology (HUST), Wuhan, 430022, China.

Email: 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。

Yiyu Wang, Department of Dermatology, Air Force Medical Center, PLA, Beijing, China.

Email: 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。

Abstract

Background: The delicate periorbital region is susceptible to skin dehydration, wrinkles, and loss of elasticity. Thus, targeted and effective anti-aging interventions are necessary for the periorbital area.

Aim: To evaluate the efficacy and safety of a new anti-aging eye cream formulated with the active complex (Yeast/rice fermentation filtrate, N-acetylneuraminic acid, palmityl tripeptide-1, and palmitoyl tetrapeptide-7).

Methods: The cell viability and expressions of key extracellular matrix (ECM) components of the active complex were evaluated using a human skin fibroblast model. In the 12-week clinical trial, skin hydration, elasticity, facial photographs, and collagen density following eye cream application were assessed using Corneometer, Cutometer, VISIA, and ultrasound device, respectively. Dermatologists and participants evaluated clinical efficacy and safety at baseline, and after 4, 8, and 12 weeks.

Results: PCR and immunofluorescent analyses revealed that the active complex significantly stimulated fibroblast proliferation (p < 0.05) and markedly promote the synthesis of collagen and elastin. Clinical findings exhibited a substantial enhancement in skin hydration (28.12%), elasticity (18.81%), and collagen production (54.99%) following 12 weeks of eye cream application. Dermatological evaluations and participants’ assessments reported a significant improvement in skin moisture, roughness, elasticity, as well as fine lines and wrinkles by week 8.

Conclusion: The new anti-aging eye cream, enriched with the active complex, demonstrates comprehensive rejuvenating effects, effectively addressing aging concerns in the periorbital area, coupled with a high safety profile.

KEYWORDS anti-aging, collagen, elastin, extracellular matrix, eye cream, wrinkle

This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

© 2024 The Author(s). Skin Research and Technology published by John Wiley & Sons Ltd.

Custom Mod Mega1

主任医师、教授、博导，南方医科大学第三附属医院（广东省骨科医院）院长

伤口世界

近100年乳腺癌的外科治疗演变，是医生不懈的努力！

安全过年 ll 年关了，价值过万的鱼刺，长啥样？

面对急性腹痛，患者、家属、医生均需重视的问题！

患胆结石的母子二人，胆囊切除后的生活质量变化竟然是？

我们从洗脚开始，1月治愈94岁婆婆两年的烂脚！

急诊外科轮转那年的儿童节，用完备用的小手术包！

学术会议

伤口世界提示

Custom Mod Mega1

主任医师、教授、博导，南方医科大学第三附属医院（广东省骨科医院）院长

伤口世界

近100年乳腺癌的外科治疗演变，是医生不懈的努力！

安全过年 ll 年关了，价值过万的鱼刺，长啥样？

面对急性腹痛，患者、家属、医生均需重视的问题！

患胆结石的母子二人，胆囊切除后的生活质量变化竟然是？

我们从洗脚开始，1月治愈94岁婆婆两年的烂脚！

急诊外科轮转那年的儿童节，用完备用的小手术包！

消息订阅

学术会议

伤口世界提示