伤口世界

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星期二, 22 10月 2019

关于伤口那些事—伤口疼痛

原创：伤口治疗及造口护理中心

一旦有伤口出现，往往会有疼痛的症状发生，这些疼痛反复发作，让许多患者困扰不已。实际上导致患者出现伤口疼痛有些是伤口愈合期间的正常症状，有些由于伤口感染等原因导致，我们应该区别对待，区别处理。

星期二, 22 10月 2019

关于营养的那些事—营养素

原创：伤口治疗及造口护理中心

伤口的愈合除了需要良好的环境以外，必不可少的就是需要充足的营养物质的提供。今天小编就给大家介绍一下与伤口愈合紧密相关的一些营养素（分为两次课程）。

星期二, 22 10月 2019

对于每一个人来说、食物中富含营养素的多少，及其自身吸收利用的程度的高低，将决定着他本人的营养状况。目前对一个人营养状况的评价，大体上是根据我国各类人群中每日膳食营养素供给量的标准米衡量的。对符合每日供给量标准的为营养状况良好，超过的为营养过剩，不足的为营养不良。受历史条件的限制，祖国医学认为人的营养状况取决于饮食结构与进食量是否合理，合理的饮食结构能保障营养素的供给，所以营养状态良好的饮食标准应该是下面几点。

星期二, 22 10月 2019

关于压力性损伤的那些事—家庭护理（2）

原创：伤口治疗及造口护理中心

接着我们上一次内容，如果压力性损伤一旦发生，我们的家庭护理重点将从预防转成减缓其发展和促进愈合。那么愈合减缓压力性损伤的发展内？

星期二, 22 10月 2019

关于压力性损伤的那些事—分期

原创：伤口治疗及造口护理中心

四月已接近尾声，五月已悄悄来临，对于每一位护士来说，五月是不平凡的一月。5.12护士节马上就要来临了，小编作为临床护理工作岗位上的普通一员，心里也是异常激动，无论是院里还是市里都筹备着丰富多彩的节目和各项比赛。应领导号召，小编自己也积极参加各项活动。但无奈分身乏术。在此向大家致歉，没有及时更新内容。让各位读者久等了。再次向大家致歉。今天小编就向大家继续讲解关于压力性损伤的相关内容。

K2 Content

异体表皮干细胞对裸鼠全层皮肤缺损创面移植异体全厚皮成活的影响及其机制 2024-11-22 00:00

黄韶斌 1 胡志成 1 张逸 2 唐冰 1 王鹏 1 徐海琳 1 王志勇 1 董云先 1 程璞 1 荣燕超 1 吴军 3 朱家源 1

1 中山大学附属第一医院烧伤科，广州 510080；

2 南通大学附属医院烧伤整形外科 226001；3 深圳大学第一附属医院烧伤整形科 518037 通信作者：朱家源，Email：该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。
Novel Cosmetic Ingredient CS-AA Polyion Complex and Skin Moisturizing Effect 2024-11-20 00:00

Hyungjoon Jeon Yong Won Shin Jong Gu Won Nojin Park Sang-Wook Park Nam Seo Son Mi-Sun Kim

LG Household & Health Care (LG H&H), LG Science Park R&D Center, Seoul, Republic of Korea

Correspondence: Hyungjoon Jeon (该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。) Mi-Sun Kim (该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。)

Received: 29 January 2024

Revised: 21 June 2024

Accepted: 19 July 2024

Keywords: arginine | chondroitin sulfate | glutamine | skin hydration | TEWL | water-holding capacity

ABSTRACT

Purpose: The study explored the enhanced skin moisturizing capabilities and moisture retention effects achieved by forming a polyion complex using sulfated glycosaminoglycan (GAG), specifically chondroitin sulfate (CS), and amino acids (AA) such as glutamine (Q) and arginine (R). The overall hydration effect of this CS-AA complex was examined.

Methods: After analyzing the CS-AA polyion complex structure using spectroscopic methods, the ex vivo moisture retention ability was assessed under dry conditions using porcine skin samples. Additionally, the efficacy of the CS-AA polyion complex in reducing transepidermal water loss (TEWL) and improving skin hydration was evaluated on human subjects using a digital evaporimeter and a corneometer, respectively.

Results: Validating a systematic reduction in particle size, the following order was observed: CS > CS/AA simple mixture > CSAA complex based on dynamic light scattering (DLS) and transmission electron microscopy (TEM) analysis. Furthermore, observations revealed that the CS-AA complex exhibits negligible surface charge. Additionally, Fourier-transform infrared spectroscopy (FT-IR) analysis demonstrated a distinct peak shift in the complex, confirming the successful formation of the CS-AA complex. Subsequently, the water-holding effect through porcine skin was assessed, revealing a notable improvement in moisture retention (weight loss) for the CS-Q complex: 40.6% (1 h), 20.5% (2 h), and 18.7% (4 h) compared to glycerin. Similarly, the CS-R complex demonstrated enhancements of 50.2% (1 h), 37.5% (2 h), and 33% (4 h) compared to glycerin. Furthermore, TEWL improvement efficacy on human skin demonstrated approximately 25% improvement for both the CS-Q complex and CS-R complex, surpassing the modest 12.5% and 18% improvements witnessed with water and glycerin applications, respectively. Finally, employing a corneometer, hydration changes in the skin were monitored over 4 weeks. Although CS alone exhibited nominal alterations, the CS-Q complex and CS-R complex showed a significant increase in moisture levels after 4 weeks of application.

Conclusion: In this study, polyion complexes were successfully formed between CS, a sulfated GAG, and AA. Comparisons with glycerin, a well-known moisturizing agent, confirmed that the CS-AA complex exhibits superior moisturizing effects in various aspects. These findings suggest that the CS-AA complex is a more effective ingredient than CS or AA alone in terms of efficacy.
Comprehensive evaluation of the efficacy and safety of a new multi-component anti-aging topical eye cream 2024-11-19 00:00

Fan Yang1 Xinyuan Zhang2 Hua Wang1 Miao Guo1 Jinlong Zhang1 Xuejiao Feng3 Jiayi Yu3 Jiahui Yang3 Jinjin Zhu4 Yiyu Wang3

1 Research & Development Center, Mageline Biology Tech Co., Ltd, Wuhan, Hubei, China

2 Shanghai Skinshield Clinical Testing and Technological Research Ltd., Shanghai, China

3 Department of Dermatology, Air Force Medical Center, PLA, Beijing, China

4 Department of Dermatology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology (HUST), Wuhan, China

Correspondence

Jinjin Zhu, Department of Dermatology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology (HUST), Wuhan, 430022, China.

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Yiyu Wang, Department of Dermatology, Air Force Medical Center, PLA, Beijing, China.

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Abstract

Background: The delicate periorbital region is susceptible to skin dehydration, wrinkles, and loss of elasticity. Thus, targeted and effective anti-aging interventions are necessary for the periorbital area.

Aim: To evaluate the efficacy and safety of a new anti-aging eye cream formulated with the active complex (Yeast/rice fermentation filtrate, N-acetylneuraminic acid, palmityl tripeptide-1, and palmitoyl tetrapeptide-7).

Methods: The cell viability and expressions of key extracellular matrix (ECM) components of the active complex were evaluated using a human skin fibroblast model. In the 12-week clinical trial, skin hydration, elasticity, facial photographs, and collagen density following eye cream application were assessed using Corneometer, Cutometer, VISIA, and ultrasound device, respectively. Dermatologists and participants evaluated clinical efficacy and safety at baseline, and after 4, 8, and 12 weeks.

Results: PCR and immunofluorescent analyses revealed that the active complex significantly stimulated fibroblast proliferation (p < 0.05) and markedly promote the synthesis of collagen and elastin. Clinical findings exhibited a substantial enhancement in skin hydration (28.12%), elasticity (18.81%), and collagen production (54.99%) following 12 weeks of eye cream application. Dermatological evaluations and participants’ assessments reported a significant improvement in skin moisture, roughness, elasticity, as well as fine lines and wrinkles by week 8.

Conclusion: The new anti-aging eye cream, enriched with the active complex, demonstrates comprehensive rejuvenating effects, effectively addressing aging concerns in the periorbital area, coupled with a high safety profile.

KEYWORDS anti-aging, collagen, elastin, extracellular matrix, eye cream, wrinkle

This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

© 2024 The Author(s). Skin Research and Technology published by John Wiley & Sons Ltd.

Custom Mod Mega1

主任医师、教授、博导，南方医科大学第三附属医院（广东省骨科医院）院长

伤口世界

关于伤口那些事—伤口疼痛

关于营养的那些事—营养素

关于营养的那些事—营养素

关于营养的那些事—摄入量

关于压力性损伤的那些事—家庭护理（2）

关于压力性损伤的那些事—分期

学术会议

伤口世界提示

Custom Mod Mega1

主任医师、教授、博导，南方医科大学第三附属医院（广东省骨科医院）院长

伤口世界

关于伤口那些事—伤口疼痛

关于营养的那些事—营养素

关于营养的那些事—营养素

关于营养的那些事—摄入量

关于压力性损伤的那些事—家庭护理（2）

关于压力性损伤的那些事—分期

消息订阅

学术会议

伤口世界提示