如何选择正确、适宜的伤口敷料

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Custom Mod Mega1

主任医师、教授、博导，南方医科大学第三附属医院（广东省骨科医院）院长

中德骨科伤口管理学校校长

广东省骨科研究院运动医学研究所所长

广东省内运动医学专业唯一的博士研究生导师

美国哈弗大学医学院骨科访问学者

专业特长处于省内领先、国内或国际先进水平以上

2018年获得“国之名医卓越建树”荣誉称号

2017年被评为全国卫生计生系统先进工作者、广东省医学领军人才

中国医师协会运动医师分会副会长

STCOT中国部运动医学分会副主任委员

广东省医学会关节外科分会主任委员

广东省医学会运动医学会分会名誉主任委员

独立承担过国家“863”课题，主持过10余项省、部级科研项目

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Radiofrequency Treatment Attenuates Age-Related Changes in Dermal–Epidermal Junctions of Animal Skin 2024-12-25 00:00

Kyung-A Byun 1,2,3,†, Hyoung Moon Kim 4,† , Seyeon Oh 3 , Sosorburam Batsukh 1,3, Kuk Hui Son 5,* and Kyunghee Byun 1,3,6,*

1 Department of Anatomy & Cell Biology, College of Medicine, Gachon University, Incheon 21936, Republic of Korea

2 LIBON Inc., Incheon 22006, Republic of Korea

3 Functional Cellular Networks Laboratory, Lee Gil Ya Cancer and Diabetes Institute, Gachon University, Incheon 21999, Republic of Korea

4 Maylin Anti-Aging Center Ilsan, Goyang 10391, Republic of Korea

5 Department of Thoracic and Cardiovascular Surgery, Gachon University Gil Medical Center, Gachon University, Incheon 21565, Republic of Korea

6 Department of Health Sciences and Technology, Gachon Advanced Institute for Health & Sciences and Technology (GAIHST), Gachon University, Incheon 21999, Republic of Korea

* Correspondence: 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。 (K.H.S.); 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。 (K.B.); Tel.: +82-32-460-3666 (K.H.S.); +82-32-899-6511 (K.B.)

† These authors contributed equally to this work.

Abstract: The dermal–epidermal junction (DEJ) is essential for maintaining skin structural integrity and regulating cell survival and proliferation. Thus, DEJ rejuvenation is key for skin revitalization, particularly in age-related DEJ deterioration. Radiofrequency (RF) treatment, known for its ability to enhance collagen fiber production through thermal mechanisms and increase heat shock protein (HSP) expression, has emerged as a promising method for skin rejuvenation. Additionally, RF activates Piezo1, an ion channel implicated in macrophage polarization toward an M2 phenotype and enhanced TGF-β production. This study investigated the impact of RF treatment on HSP47 and HSP90 expression, known stimulators of DEJ protein expression. Furthermore, using in vitro and aged animal skin models, we assessed whether RF-induced Piezo1 activation and the subsequent M2 polarization could counter age-related DEJ changes. The RF treatment of H2O2 -induced senescent keratinocytes upregulated the expression of HSP47, HSP90, TGF-β, and DEJ proteins, including collagen XVII. Similarly, the RF treatment of senescent macrophages increased Piezo1 and CD206 (M2 marker) expression. Conditioned media from RF-treated senescent macrophages enhanced the expression of TGF-β and DEJ proteins, such as nidogen and collagen IV, in senescent fibroblasts. In aged animal skin, RF treatment increased the expression of HSP47, HSP90, Piezo1, markers associated with M2 polarization, IL-10, and TGF-β. Additionally, RF treatment enhanced DEJ protein expression. Moreover, RF reduced lamina densa replication, disrupted lesions, promoted hemidesmosome formation, and increased epidermal thickness. Overall, RF treatment effectively enhanced DEJ protein expression and mitigated age-related DEJ structural changes by increasing HSP levels and activating Piezo1.

Keywords: aged mice skin; bipolar; dermal–epidermal junction; heat shock protein; monopolar; Piezo1; radiofrequency

Citation: Byun, K.-A.; Kim, H.M.; Oh, S.; Batsukh, S.; Son, K.H.; Byun, K. Radiofrequency Treatment Attenuates Age-Related Changes in Dermal–Epidermal Junctions of Animal Skin. Int. J. Mol. Sci. 2024, 25, 5178. https://doi.org/10.3390/ ijms25105178

Academic Editor: Terrence Piva

Received: 16 April 2024

Revised: 3 May 2024

Accepted: 7 May 2024

Published: 9 May 2024

Copyright: © 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/).

Epidermal stem cells: skin surveillance and clinical perspective 2024-12-24 00:00

Xin Tang1†, Jiaqi Wang1†, Jiaoling Chen1†, Wanting Liu1 , Pei Qiao1 , Huiyi Quan1 , Zhiguo Li1 , Erle Dang1 , Gang Wang1* and Shuai Shao1*

Abstract

The skin epidermis is continually infuenced by a myriad of internal and external elements. At its basal layer reside epidermal stem cells, which fuels epidermal renovation and hair regeneration with powerful self-renewal ability, as well as keeping diverse signals that direct their activity under surveillance with quick response. The importance of epidermal stem cells in wound healing and immune-related skin conditions has been increasingly recognized, and their potential for clinical applications is attracting attention. In this review, we delve into recent advancements and the various physiological and psychological factors that govern distinct epidermal stem cell populations, including psychological stress, mechanical forces, chronic aging, and circadian rhythm, as well as providing an overview of current methodological approaches. Furthermore, we discuss the pathogenic role of epidermal stem cells in immune-related skin disorders and their potential clinical applications.

Keywords Epidermal stem cells, Aging, Wound healing, Immune-related skin disorders, Regeneration

† Xin Tang, Jiaqi Wang and Jiaoling Chen contributed equally to this work.

*Correspondence:

Gang Wang

该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。

Shuai Shao

该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。

1 Department of Dermatology, Xijing Hospital, Fourth Military Medical University, Xi’an 710032, Shannxi, China

© The Author(s) 2024. Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modifed the licensed material. You do not have permission under this licence to share adapted material derived from this article or parts of it. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc-nd/4.0/.
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如何选择正确、适宜的伤口敷料

How to choose the appropriate dressing for each wound type
如何选择适宜的伤口敷料

根据患者全身情况和伤口状况选择合适的敷料对于促进伤口愈合和改善患者生活质量至关重要。但敷料种类繁多，各种敷料之间的结构和特性不同，适应症也会大不同。如何选择正确的敷料是伤口护士和医生每天都会面对的挑战。

伤口愈合有其固有的生理机制和过程，敷料因材质而有所不同，但都是以解决伤口愈合过程某一环节的问题设计的，慢性伤口的治疗之所以复杂除了因为涉及的病因复杂和患者个体化差异大之外，在制定治疗策略时往往会受到施治者本身知识水平和经验的影响，很难标准化，包括对敷料的理解和驾驭的能力，都会使伤口的预后变得难以预测。

（慢性伤口——糖尿病足）

慢性伤口治疗需要在伤口不同愈合期，结合患者情况，选择适宜的敷料，只有对不同类型敷料的特性充分了解，加上经验的积累，方可做到轻松自如地驾驭各种敷料。

敷料可以根据其结构和功能分为几大类，每一大类又可分为不同类型。从临床应用的角度可以简单分为以下几大类：

1透明膜敷料
2敷贴类
3防粘连敷料
4湿性敷料
5吸收性敷料

伤口专科护士的职责之一：

　　在评估患者情况和伤口情况后选择适合的敷料，这个过程也要听取医生意见建议，但最重要的是要以患者为中心，达到好的效果的同时，不能给患者带来不必要的不舒适感和疼痛等。

现在我们来分类学习下:

学术会议

2019广东省医疗行业协会伤口管理分会年会

扫一扫了解详情:

2019年6月15日中国广州
主办单位：广东省医疗行业协会伤口管理分会

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