何黎
[摘 要] 广义的皮肤屏障包括物理屏障、神经屏障、色素屏障及免疫屏障。 狭义的皮肤屏障通常指表皮屏障。 既往研究主要集中在角质层,忽视了表皮其他层次的屏障修复。 近年研究表明,多种皮肤疾病及皮肤问题的表皮屏障受损不仅在角质层,还涉及颗粒层、棘层及基底层,且角化包膜、细胞间脂质及紧密连接蛋白变化也是表皮屏障受损的关键因素。 但迄今为止,仍缺乏对表皮屏障不同层次受损机制及干预的系统探讨。 本文提出“表皮屏障受损及分层修复”新理念,为表皮屏障受损不同层次的精准修复提供理论依据及临床应用新视角。
[关键词] 皮肤屏障;表皮屏障;屏障修复;紧密连接蛋白
[中图分类号] R 751 [文献标志码] A [文章编号] 1001 - 7089(2025)09 - 0945 - 08[DOI] 10. 13735 / j. cjdv. 1001⁃7089. 202502028
The New Concept of “Epidermal Barrier Damage and Stratified Repair”HE Li1,2
(1. Department of Dermatology,First Affiliated Hospital of Kunming Medical University, Kunming650032,China; 2. Liwa Institute of Skin Health, East China Normal University,Shanghai 200062,China)
[Abstract] The skin barrier in a broad sense includes the physical barrier, neural barrier,pigment barrier, and immune barrier, while the skin barrier in a narrow sense generally refers to the epidermal barrier. Previous studies have mainly focused on thestratum corneum, neglecting barrier repair in other epidermal layers. Recent studies have revealed that epidermal barrier damage in various dermatoses and skin conditions involves not only the stratum corneum but also the stratum granulosum, stratum spinosum, and stratum basale, with alterations in the cornified envelope, intercellular lipids, and tight junction proteins being key contributing factors. However, systematic investigations into the damage mechanisms and targeted interventions for different epidermal barrier layers remain lacking. This article proposes the new concept of “ epidermal barrier damage and stratified repair ”, providing both a theoretical framework and new clinical insights for layer⁃specific precision repair of the epidermal barrier.
[Key words] Skin barrier;Epidermal barrier;Barrier repair;Tight junction proteins
中华医学会医学美容学会激光美容学组,中华医学会皮肤性病学会美容激光学组
[关键词] 皮肤黏膜修复,光声电治疗术后;共识
[中图分类号] R751.05 [文献标识码] B [文章编号] 1000-4963(2019)05-0319-04
doi:10.16761/j.cnki.1000-4963.2019.05.019
从事内分泌代谢专业30余年, 对甲亢、糖尿病、肾上腺疾病等诊治有较丰富的临床经验.在糖尿病足的防治和减少糖尿病截肢率方面富有经验。
担任广东省医学会内分泌学分会委员,广东省中西医结合学会创面处理专业委员会常委,广东省医学会内科学分会副主委。承担广东省卫生厅基金一项,参与国家自然科学基金、省重点攻关课题等项目5项,发表学术论文20余篇,主编专著1部,副主编3部,参编3部,获校优秀教学一等奖、二等奖各一次。2017年获羊城好医生,2018年获评岭南名医。
伤口世界平台生态圈,以“关爱人间所有伤口患者”为愿景,连接、整合和拓展线上和线下的管理慢性伤口的资源,倡导远程、就近和居家管理慢性伤口,解决伤口专家的碎片化时间的价值创造、诊疗经验的裂变复制、和患者的就近、居家和低成本管理慢性伤口的问题。
2019广东省医疗行业协会伤口管理分会年会
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