Lara Camillo, Elisa Zavattaro and Paola Savoia *
Department of Health Science, Università del Piemonte Orientale, 28100 Novara, Italy;
该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。 (L.C.); 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。 (E.Z.)
* Correspondence: 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。; Tel.: +39-0321-373-3387
Academic Editor: Adam Reich
Received: 30 December 2024
Revised: 23 January 2025
Accepted: 27 January 2025
Published: 1 February 2025
Citation: Camillo, L.; Zavattaro, E.; Savoia, P. Nicotinamide: A
Multifaceted Molecule in Skin Health and Beyond. Medicina 2025, 61, 254.
https://doi.org/10.3390/ medicina61020254
Copyright: © 2025 by the authors. Published by MDPI on behalf of the Lithuanian University of Health Sciences. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/ licenses/by/4.0/)
Abstract: Nicotinamide (NAM), the amide form of vitamin B3, is a precursor to essential cofactors nicotinamide adenine dinucleotide (NAD+ ) and NADPH. NAD+ is integral to numerous cellular processes, including metabolism regulation, ATP production, mitochondrial respiration, reactive oxygen species (ROS) management, DNA repair, cellular senescence, and aging. NAM supplementation has demonstrated efficacy in restoring cellular energy, repairing DNA damage, and inhibiting inflammation by suppressing proinflammatory cytokines release. Due to its natural presence in a variety of foods and its excellent safety profile—even at high doses of up to 3 g/day—NAM is extensively used in the chemoprevention of non-melanoma skin cancers and the treatment of dermatological conditions such as blistering diseases, atopic dermatitis, rosacea, and acne vulgaris. Recently, its anti-aging properties have elevated NAM’s prominence in skincare formulations. Beyond DNA repair and energy replenishment, NAM significantly impacts oxidative stress reduction, cell cycle regulation, and apoptosis modulation. Despite these multifaceted benefits, the comprehensive molecular mechanisms underlying NAM’s actions remain not fully elucidated. This review consolidates recent research to shed light on these mechanisms, emphasizing the critical role of NAM in cellular health and its therapeutic potential. By enhancing our understanding, this work underscores the importance of continued exploration into NAM’s applications, aiming to inform future clinical practices and skincare
Keywords: nicotinamide; chemoprevention; skin health; cellular oxidative stress; DNA damage; photoaging; ultraviolet radiation; inflammation; vitamin B3
Kankanit Yeerong 1 , Panuwan Chantawannakul 2 , Songyot Anuchapreeda 3,4 , Thomas Rades 5 ,
Anette Müllertz 5,6 and Wantida Chaiyana 1,4,7,*
1 Department of Pharmaceutical Sciences, Faculty of Pharmacy, Chiang Mai University, Chiang Mai 50200, Thailand; 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。
2 Bee Protection Laboratory, Department of Biology, Faculty of Science, Chiang Mai University, Chiang Mai 50200, Thailand; 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。
3 Division of Clinical Microscopy, Department of Medical Technology, Faculty of Associated Medical Sciences, Chiang Mai University, Chiang Mai 50200, Thailand; 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。
4 Center of Excellence in Pharmaceutical Nanotechnology, Faculty of Pharmacy, Chiang Mai University, Chiang Mai 50200, Thailand
5 Department of Pharmacy, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, 2100 Copenhagen, Denmark; 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。 (T.R.); 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。 (A.M.)
6 Bioneer:FARMA, Department of Pharmacy, University of Copenhagen, Universitetsparken 2, 2100 Copenhagen, Denmark
7 Multidisciplinary and Interdisciplinary School, Chiang Mai University, Chiang Mai 50200, Thailand *
Correspondence: 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。
Abstract: Acheta domesticus is an edible insect, rich in nutritional value and considered a sustainable protein source. This study aimed to investigate the potential application of A. domesticus extracts for anti-skin-aging purposes. The extracts were prepared by maceration at ambient temperature with 95% ethanol or hexane and maceration in gentle heat (45 ◦C) with 95% v/v ethanol or DI water. The extracts were examined for total protein, phenolic, and flavonoid contents. Protein molecular weight distribution was analyzed. The safety of the extracts was investigated in terms of irritation and cytotoxicity. Biological activities relevant to the inhibition of skin aging were evaluated, including increasing transforming growth factor-beta 1 (TGF-β1) expression and inhibitory activities on collagenase and hyaluronidase. The aqueous extract from maceration in gentle heat had the highest total protein content (63 ± 1% w/w), total phenolic content (0.48 ± 0.03 mg GAE/g extract), TGF-β1
stimulating activities (33 ± 2 pg/mL), and collagenase inhibition (with a half maximal inhibitory
concentration of 26 ± 1 µg/mL) among various extracts investigated. It caused no irritation to the
hen’s egg chorioallantoic membrane and showed no cytotoxicity to human dermal fibroblasts and
peripheral blood mononuclear cells. Therefore, aqueous A. domesticus extract is proposed as an
innovative natural anti-skin-aging ingredient.
Keywords: Acheta domesticus; anti-aging skincare; cosmetic; human dermal fibroblast; safety
伤口世界为希望了解慢性伤口/溃疡的原因和管理的患者与私人护理人员提供信息。
创伤愈合是指机体遭受外力作用，皮肤等组织出现离断或缺损后的愈复过程，包括各种组织的再生和肉芽组织增生、瘢痕组织形成的复杂组合，表现出各种过程的协同作用。伤口创伤愈合的基本过程:急性炎症期→细胞增生期→瘢痕形成期→表皮及其它组织再生。根据损伤程度及有无感染，创伤愈合可分为一期愈合、二期愈合、三期愈合3种类型。
健康、关爱、诚信、务实、开拓、创新
让天下没有治不好的伤口。Chinomise, no incurable wound in the world.
伤口世界平台生态圈，以“关爱人间所有伤口患者”为愿景，连接、整合和拓展线上和线下的管理慢性伤口的资源，倡导远程、就近和居家管理慢性伤口，解决伤口专家的碎片化时间的价值创造、诊疗经验的裂变复制、和患者的就近、居家和低成本管理慢性伤口的问题。
2019广东省医疗行业协会伤口管理分会年会
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