付洋

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14 11月 2019

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Author : 伤口世界

擅长：各种烧伤治疗、表皮肿物去除和皮瓣成形、体表瘢痕防治，糖尿病足、褥疮、慢性难愈性创面的治疗；面部、胸部整形，自体脂肪移植。

本科就读于北京大学医学部，研究生师从海军军医大学烧伤科夏照帆院士，钻研学术同时锻炼临床技能

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Surface Inactivation of a SARS‑CoV‑2 Surrogate with Hypochlorous Acid is Impacted by Surface Type, Contact Time, Inoculum Matrix, and Concentration
Correlation and Agreement Between Transcutaneous Oxygen Pressure and Toe Pressure in Patients with Diabetic Foot Ulcers
Status Report on Topical Hypochlorous Acid: Clinical Relevance of Specific Formulations, Potential Modes of Action, and Study Outcomes
Effect of Stabilized Hypochlorous Acid on Re-epithelialization and Bacterial Bioburden in Acute Wounds: A Randomized Controlled Trial in Healthy Volunteers
Purification of human iPSC-derived cells at large scale using microRNA switch and magnetic-activated cell sorting

K2 Content

Surface Inactivation of a SARS‑CoV‑2 Surrogate with Hypochlorous Acid is Impacted by Surface Type, Contact Time, Inoculum Matrix, and Concentration 2026-08-10 00:00

Allyson N. Hamilton¹ · Sahaana Chandran¹ · Christopher A. Baker^1,2 · Kristen E. Gibson¹

Received: 2 December 2022 / Accepted: 13 January 2023 / Published online: 21 January 2023

© The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2023

Abstract

Indirect contact with contaminated surfaces is a potential transmission route for COVID-19. Therefore, it is necessary to investigate convenient and inexpensive surface sanitization methods, such as HOCl, against severe acute respiratory syn-drome coronavirus 2 (SARS-CoV-2). The SARS-CoV-2 surrogate, Phi6 (~7 log PFU/mL), was prepared in artificial saliva and tripartite matrices, spot inoculated on coupons of either stainless steel or vinyl, and allowed to dry. The coupons were sprayed with either 500 ppm or 1000 ppm HOCl, and remained on the surface for 0 s (control), 5 s, 30 s, or 60 s. Samples were enumerated via the double agar overlay assay. Statistical analysis was completed in R using a generalized linear model with Quasipoisson error approximations. Time, concentration, surface type, and inoculum matrix were all significant contributors to log reduction at P=0.05. Significant three-way interactions were observed for 1000 ppm, vinyl, and 60 s (P=0.03) and 1000 ppm, tripartite, and 60 s (P=0.0121). A significant two-way interaction between vinyl and 60 s was also observed (P=0.0168). Overall, increased HOCl concentration and exposure time led to increased Phi6 reduction. Notably, the highest estimated mean log reduction was 3.31 (95% CI 3.14, 3.49) for stainless steel at 60 s and 1000 ppm HOCl in artificial saliva, indicating that this method of sanitization may not adequately reduce enveloped viruses to below infective thresholds.

Keywords Fomite · Phi6 · Hypochlorous acid · Vinyl · Stainless steel
Correlation and Agreement Between Transcutaneous Oxygen Pressure and Toe Pressure in Patients with Diabetic Foot Ulcers 2026-08-08 00:00

Kyu-Il Lee¹ , Yu-Kyeong Yun² , Seung-Kyu Han^2,3 , Kyung-Chul Moon^2,3 , Sik Namgoong^2,3 ,

Seong-Ho Jeong³ , Eun-Sang Dhong³

¹Department of Plastic Surgery, Taean Public Health Office, Taean, Korea

²Diabetic Wound Center and Department of Plastic Surgery, Korea University Guro Hospital, Seoul, Korea

³Department of Plastic Surgery, Korea University College of Medicine, Seoul, Korea

Abstract

Background: Adequate tissue oxygenation is a key determinant of diabetic foot ulcer (DFU) outcomes. Though transcutaneous oxygen pressure (TcPO₂) is the gold standard for evaluating tissue oxygenation, its limited availability restricts routine clinical use. Consequently, toe pressure is frequently utilized as a practical surrogate; however, the direct correlation between these two modalities has yet to be rigorously investigated. This study aimed to assess the correlation and agreement between TcPO₂and toe pressure in patients with DFUs.

Methods: A retrospective review was conducted on 837 DFU patients who received simultaneous TcPO²and toe pressure assessments.

The correlation between the two tests was analyzed using the Pearson correlation coefficient, and agreement was evaluated using Bland– Altman analysis. To aid interpretation, a scatterplot and Bland–Altman plot were generated.

Results: TcPO₂and toe pressure demonstrated a strong correlation (R=0.66; 95% confidence interval, 0.62 to 0.70; P<0.001). Bland–

Altman analysis showed a mean bias of 26.9 mmHg (standard deviation of differences, 28.8 mmHg; 95% limits of agreement, −28.9 to 82.6 mmHg) between toe pressure and TcPO₂, reflecting limited agreement and increased variability at higher perfusion levels.

Conclusion: TcPO₂and toe pressure are strongly correlated. However, they are not interchangeable, particularly in DFU patients with high tissue perfusion.

Keywords: Diabetic foot; Foot ulcer; Ischemia; Microcirculation
Status Report on Topical Hypochlorous Acid: Clinical Relevance of Specific Formulations, Potential Modes of Action, and Study Outcomes 2026-08-07 00:00

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付洋

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