伤口世界

电子邮件地址: 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。

星期五, 20 9月 2019

经验分享：负压引流处理造口旁感染粪水倒流入腹腔的感染性休克

原创：胡海涛负压引流与创面修复

多年经历总结：结肠穿孔术后患者，要经过很多劫难才能恢复！

这个患者，经历了造口旁出血、造口旁裂开并感染、粪水倒流进腹腔休克、胆囊坏疽、肝包膜下感染等等！

星期五, 20 9月 2019

抠痘痘，引发的一场惨案

负压引流与创面修复

文章转自公众号普外时间，作者胡海涛

抠痘痘，简单不？大家肯定都做过。而说到抠痘痘的危害，可能大多数人会想到颅内感染，抠位于面部危险三角区域的痘痘，确实容易导致颅内感染，造成严重问题。

星期五, 20 9月 2019

7岁瘫痪女孩压疮3月，只因4年前爬出阳台……

原创：胡海涛负压引流与创面修复

星期四, 19 9月 2019

降温了，糖友们热水洗脚时，小心别被‘烫猪蹄儿’！

原创：萤火虫医生负压引流与创面修复

冬天足浴，是一种享受，可以促进人体脚部血液循环，达到改善脚部经络，促进人体健康的目的。

星期四, 19 9月 2019

改良封闭式负压引流技术治疗腹部手术切口感染临床研究

原创：胡海涛负压引流与创面修复

星期四, 19 9月 2019

谎言：使用胰岛素，会上瘾，导致终身依赖！

负压引流与创面修复

文章转载自公众号资讯，作者胡海涛

很多糖尿病患者听说要注射胰岛第一反应就是拒绝。

K2 Content

异体表皮干细胞对裸鼠全层皮肤缺损创面移植异体全厚皮成活的影响及其机制 2024-11-22 00:00

黄韶斌 1 胡志成 1 张逸 2 唐冰 1 王鹏 1 徐海琳 1 王志勇 1 董云先 1 程璞 1 荣燕超 1 吴军 3 朱家源 1

1 中山大学附属第一医院烧伤科，广州 510080；

2 南通大学附属医院烧伤整形外科 226001；3 深圳大学第一附属医院烧伤整形科 518037 通信作者：朱家源，Email：该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。
Novel Cosmetic Ingredient CS-AA Polyion Complex and Skin Moisturizing Effect 2024-11-20 00:00

Hyungjoon Jeon Yong Won Shin Jong Gu Won Nojin Park Sang-Wook Park Nam Seo Son Mi-Sun Kim

LG Household & Health Care (LG H&H), LG Science Park R&D Center, Seoul, Republic of Korea

Correspondence: Hyungjoon Jeon (该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。) Mi-Sun Kim (该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。)

Received: 29 January 2024

Revised: 21 June 2024

Accepted: 19 July 2024

Keywords: arginine | chondroitin sulfate | glutamine | skin hydration | TEWL | water-holding capacity

ABSTRACT

Purpose: The study explored the enhanced skin moisturizing capabilities and moisture retention effects achieved by forming a polyion complex using sulfated glycosaminoglycan (GAG), specifically chondroitin sulfate (CS), and amino acids (AA) such as glutamine (Q) and arginine (R). The overall hydration effect of this CS-AA complex was examined.

Methods: After analyzing the CS-AA polyion complex structure using spectroscopic methods, the ex vivo moisture retention ability was assessed under dry conditions using porcine skin samples. Additionally, the efficacy of the CS-AA polyion complex in reducing transepidermal water loss (TEWL) and improving skin hydration was evaluated on human subjects using a digital evaporimeter and a corneometer, respectively.

Results: Validating a systematic reduction in particle size, the following order was observed: CS > CS/AA simple mixture > CSAA complex based on dynamic light scattering (DLS) and transmission electron microscopy (TEM) analysis. Furthermore, observations revealed that the CS-AA complex exhibits negligible surface charge. Additionally, Fourier-transform infrared spectroscopy (FT-IR) analysis demonstrated a distinct peak shift in the complex, confirming the successful formation of the CS-AA complex. Subsequently, the water-holding effect through porcine skin was assessed, revealing a notable improvement in moisture retention (weight loss) for the CS-Q complex: 40.6% (1 h), 20.5% (2 h), and 18.7% (4 h) compared to glycerin. Similarly, the CS-R complex demonstrated enhancements of 50.2% (1 h), 37.5% (2 h), and 33% (4 h) compared to glycerin. Furthermore, TEWL improvement efficacy on human skin demonstrated approximately 25% improvement for both the CS-Q complex and CS-R complex, surpassing the modest 12.5% and 18% improvements witnessed with water and glycerin applications, respectively. Finally, employing a corneometer, hydration changes in the skin were monitored over 4 weeks. Although CS alone exhibited nominal alterations, the CS-Q complex and CS-R complex showed a significant increase in moisture levels after 4 weeks of application.

Conclusion: In this study, polyion complexes were successfully formed between CS, a sulfated GAG, and AA. Comparisons with glycerin, a well-known moisturizing agent, confirmed that the CS-AA complex exhibits superior moisturizing effects in various aspects. These findings suggest that the CS-AA complex is a more effective ingredient than CS or AA alone in terms of efficacy.
Comprehensive evaluation of the efficacy and safety of a new multi-component anti-aging topical eye cream 2024-11-19 00:00

Fan Yang1 Xinyuan Zhang2 Hua Wang1 Miao Guo1 Jinlong Zhang1 Xuejiao Feng3 Jiayi Yu3 Jiahui Yang3 Jinjin Zhu4 Yiyu Wang3

1 Research & Development Center, Mageline Biology Tech Co., Ltd, Wuhan, Hubei, China

2 Shanghai Skinshield Clinical Testing and Technological Research Ltd., Shanghai, China

3 Department of Dermatology, Air Force Medical Center, PLA, Beijing, China

4 Department of Dermatology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology (HUST), Wuhan, China

Correspondence

Jinjin Zhu, Department of Dermatology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology (HUST), Wuhan, 430022, China.

Email: 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。

Yiyu Wang, Department of Dermatology, Air Force Medical Center, PLA, Beijing, China.

Email: 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。

Abstract

Background: The delicate periorbital region is susceptible to skin dehydration, wrinkles, and loss of elasticity. Thus, targeted and effective anti-aging interventions are necessary for the periorbital area.

Aim: To evaluate the efficacy and safety of a new anti-aging eye cream formulated with the active complex (Yeast/rice fermentation filtrate, N-acetylneuraminic acid, palmityl tripeptide-1, and palmitoyl tetrapeptide-7).

Methods: The cell viability and expressions of key extracellular matrix (ECM) components of the active complex were evaluated using a human skin fibroblast model. In the 12-week clinical trial, skin hydration, elasticity, facial photographs, and collagen density following eye cream application were assessed using Corneometer, Cutometer, VISIA, and ultrasound device, respectively. Dermatologists and participants evaluated clinical efficacy and safety at baseline, and after 4, 8, and 12 weeks.

Results: PCR and immunofluorescent analyses revealed that the active complex significantly stimulated fibroblast proliferation (p < 0.05) and markedly promote the synthesis of collagen and elastin. Clinical findings exhibited a substantial enhancement in skin hydration (28.12%), elasticity (18.81%), and collagen production (54.99%) following 12 weeks of eye cream application. Dermatological evaluations and participants’ assessments reported a significant improvement in skin moisture, roughness, elasticity, as well as fine lines and wrinkles by week 8.

Conclusion: The new anti-aging eye cream, enriched with the active complex, demonstrates comprehensive rejuvenating effects, effectively addressing aging concerns in the periorbital area, coupled with a high safety profile.

KEYWORDS anti-aging, collagen, elastin, extracellular matrix, eye cream, wrinkle

This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

© 2024 The Author(s). Skin Research and Technology published by John Wiley & Sons Ltd.

Custom Mod Mega1

主任医师、教授、博导，南方医科大学第三附属医院（广东省骨科医院）院长

伤口世界

经验分享：负压引流处理造口旁感染粪水倒流入腹腔的感染性休克

抠痘痘，引发的一场惨案

7岁瘫痪女孩压疮3月，只因4年前爬出阳台……

降温了，糖友们热水洗脚时，小心别被‘烫猪蹄儿’！

改良封闭式负压引流技术治疗腹部手术切口感染临床研究

谎言：使用胰岛素，会上瘾，导致终身依赖！

学术会议

伤口世界提示

Custom Mod Mega1

主任医师、教授、博导，南方医科大学第三附属医院（广东省骨科医院）院长

伤口世界

经验分享：负压引流处理造口旁感染粪水倒流入腹腔的感染性休克

抠痘痘，引发的一场惨案

7岁瘫痪女孩压疮3月，只因4年前爬出阳台……

降温了，糖友们热水洗脚时，小心别被‘烫猪蹄儿’！

改良封闭式负压引流技术治疗腹部手术切口感染临床研究

谎言：使用胰岛素，会上瘾，导致终身依赖！

消息订阅

学术会议

伤口世界提示