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星期三, 11 9月 2019

糖尿病足的感染：2019年版IWGDF有关糖尿病足指南的学习心得（十）

原创：十六点五中山二院糖尿病足中心

如糖尿病外周血管病变那节一样，2019年版IWGDF指南在糖尿病足感染治疗这一节的后面，直接承认全身抗感染作用有“许多没有确定的领域（uncertainty regarding many areas）”附上了一大段“最需要进一步研究的领域”，共有10条，主要集中在糖尿病足感染的评估、糖尿病足慢性骨髓炎的诊断及治疗、分子生物学方法在糖尿病足感染评价的价值、糖尿病足创面局部抗菌治疗的评价等，实际上是我们之前心得中重点提出的不同看法及国内制定糖尿病足指南的难点，如何能够用经典的临床研究方法进行研究是一个非常头痛的问题。

星期三, 11 9月 2019

糖尿病足的感染（下）：2019年版IWGDF有关糖尿病足指南的学习心得（九）

原创：十六点五中山二院糖尿病足中心

（7）在糖尿病足感染中的还有一个重要的问题，就是骨髓炎的问题。而骨髓炎的问题又可以分为诊断（评估）和治疗。

星期三, 11 9月 2019

糖尿病足的感染（中）：2019年版IWGDF有关糖尿病足指南的学习心得（八）

原创：十六点五中山二院糖尿病足中心

（4）糖尿病足的感染，不但是局部的问题，而且还是全身的问题，一方面，糖尿病人全身抵抗力的下降，葡萄糖对重要脏器的损害，造成糖尿病足的感染即难控制又对全身脏器的功能影响大，很容易导致心衰、肾衰等，或者加重有关脏器的损伤；

星期三, 11 9月 2019

糖尿病足的感染（上）：2019年版IWGDF有关糖尿病足指南的学习心得（七）

原创：十六点五中山二院糖尿病足中心

糖尿病足部的慢性溃疡是否存在感染，好像应该是没有多少疑问的，但在所谓的“神经性溃疡”的表面是否存在有临床意义的感染，一直有争议。

星期三, 11 9月 2019

糖尿病外周血管病变诊疗（下）：2019年版IWGDF有关糖尿病足指南的学习心得（六）

原创：十六点五中山二院糖尿病足中心

对于外周血管病变的介入治疗，较IWGDF指南较有关OFFLOADING的细节描述，有关介入治疗的部分实在是比较粗慥，目前糖尿病外周血管病变介入治疗的热点问题大部分都没有涉及

星期三, 11 9月 2019

糖尿病外周血管病变诊疗（中）：2019年版IWGDF有关糖尿病足指南的学习心得（五）

原创：十六点五中山二院糖尿病足中心

对于糖尿病外周血管病变的治疗，2019年版IWGDF指南讲的比较少，无论是内科治疗还是介入治疗，这版的指南都讲得比较少（其实之前版本的IWGDF指南有关血管病变方面的内容更少），而国内糖尿病足指南，提到有关糖尿病外周血管病变治疗，一般都会用比较大的篇幅谈到其内科治疗。

K2 Content

异体表皮干细胞对裸鼠全层皮肤缺损创面移植异体全厚皮成活的影响及其机制 2024-11-22 00:00

黄韶斌 1 胡志成 1 张逸 2 唐冰 1 王鹏 1 徐海琳 1 王志勇 1 董云先 1 程璞 1 荣燕超 1 吴军 3 朱家源 1

1 中山大学附属第一医院烧伤科，广州 510080；

2 南通大学附属医院烧伤整形外科 226001；3 深圳大学第一附属医院烧伤整形科 518037 通信作者：朱家源，Email：该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。
Novel Cosmetic Ingredient CS-AA Polyion Complex and Skin Moisturizing Effect 2024-11-20 00:00

Hyungjoon Jeon Yong Won Shin Jong Gu Won Nojin Park Sang-Wook Park Nam Seo Son Mi-Sun Kim

LG Household & Health Care (LG H&H), LG Science Park R&D Center, Seoul, Republic of Korea

Correspondence: Hyungjoon Jeon (该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。) Mi-Sun Kim (该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。)

Received: 29 January 2024

Revised: 21 June 2024

Accepted: 19 July 2024

Keywords: arginine | chondroitin sulfate | glutamine | skin hydration | TEWL | water-holding capacity

ABSTRACT

Purpose: The study explored the enhanced skin moisturizing capabilities and moisture retention effects achieved by forming a polyion complex using sulfated glycosaminoglycan (GAG), specifically chondroitin sulfate (CS), and amino acids (AA) such as glutamine (Q) and arginine (R). The overall hydration effect of this CS-AA complex was examined.

Methods: After analyzing the CS-AA polyion complex structure using spectroscopic methods, the ex vivo moisture retention ability was assessed under dry conditions using porcine skin samples. Additionally, the efficacy of the CS-AA polyion complex in reducing transepidermal water loss (TEWL) and improving skin hydration was evaluated on human subjects using a digital evaporimeter and a corneometer, respectively.

Results: Validating a systematic reduction in particle size, the following order was observed: CS > CS/AA simple mixture > CSAA complex based on dynamic light scattering (DLS) and transmission electron microscopy (TEM) analysis. Furthermore, observations revealed that the CS-AA complex exhibits negligible surface charge. Additionally, Fourier-transform infrared spectroscopy (FT-IR) analysis demonstrated a distinct peak shift in the complex, confirming the successful formation of the CS-AA complex. Subsequently, the water-holding effect through porcine skin was assessed, revealing a notable improvement in moisture retention (weight loss) for the CS-Q complex: 40.6% (1 h), 20.5% (2 h), and 18.7% (4 h) compared to glycerin. Similarly, the CS-R complex demonstrated enhancements of 50.2% (1 h), 37.5% (2 h), and 33% (4 h) compared to glycerin. Furthermore, TEWL improvement efficacy on human skin demonstrated approximately 25% improvement for both the CS-Q complex and CS-R complex, surpassing the modest 12.5% and 18% improvements witnessed with water and glycerin applications, respectively. Finally, employing a corneometer, hydration changes in the skin were monitored over 4 weeks. Although CS alone exhibited nominal alterations, the CS-Q complex and CS-R complex showed a significant increase in moisture levels after 4 weeks of application.

Conclusion: In this study, polyion complexes were successfully formed between CS, a sulfated GAG, and AA. Comparisons with glycerin, a well-known moisturizing agent, confirmed that the CS-AA complex exhibits superior moisturizing effects in various aspects. These findings suggest that the CS-AA complex is a more effective ingredient than CS or AA alone in terms of efficacy.
Comprehensive evaluation of the efficacy and safety of a new multi-component anti-aging topical eye cream 2024-11-19 00:00

Fan Yang1 Xinyuan Zhang2 Hua Wang1 Miao Guo1 Jinlong Zhang1 Xuejiao Feng3 Jiayi Yu3 Jiahui Yang3 Jinjin Zhu4 Yiyu Wang3

1 Research & Development Center, Mageline Biology Tech Co., Ltd, Wuhan, Hubei, China

2 Shanghai Skinshield Clinical Testing and Technological Research Ltd., Shanghai, China

3 Department of Dermatology, Air Force Medical Center, PLA, Beijing, China

4 Department of Dermatology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology (HUST), Wuhan, China

Correspondence

Jinjin Zhu, Department of Dermatology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology (HUST), Wuhan, 430022, China.

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Yiyu Wang, Department of Dermatology, Air Force Medical Center, PLA, Beijing, China.

Email: 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。

Abstract

Background: The delicate periorbital region is susceptible to skin dehydration, wrinkles, and loss of elasticity. Thus, targeted and effective anti-aging interventions are necessary for the periorbital area.

Aim: To evaluate the efficacy and safety of a new anti-aging eye cream formulated with the active complex (Yeast/rice fermentation filtrate, N-acetylneuraminic acid, palmityl tripeptide-1, and palmitoyl tetrapeptide-7).

Methods: The cell viability and expressions of key extracellular matrix (ECM) components of the active complex were evaluated using a human skin fibroblast model. In the 12-week clinical trial, skin hydration, elasticity, facial photographs, and collagen density following eye cream application were assessed using Corneometer, Cutometer, VISIA, and ultrasound device, respectively. Dermatologists and participants evaluated clinical efficacy and safety at baseline, and after 4, 8, and 12 weeks.

Results: PCR and immunofluorescent analyses revealed that the active complex significantly stimulated fibroblast proliferation (p < 0.05) and markedly promote the synthesis of collagen and elastin. Clinical findings exhibited a substantial enhancement in skin hydration (28.12%), elasticity (18.81%), and collagen production (54.99%) following 12 weeks of eye cream application. Dermatological evaluations and participants’ assessments reported a significant improvement in skin moisture, roughness, elasticity, as well as fine lines and wrinkles by week 8.

Conclusion: The new anti-aging eye cream, enriched with the active complex, demonstrates comprehensive rejuvenating effects, effectively addressing aging concerns in the periorbital area, coupled with a high safety profile.

KEYWORDS anti-aging, collagen, elastin, extracellular matrix, eye cream, wrinkle

This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

© 2024 The Author(s). Skin Research and Technology published by John Wiley & Sons Ltd.

Custom Mod Mega1

主任医师、教授、博导，南方医科大学第三附属医院（广东省骨科医院）院长

伤口世界

糖尿病足的感染：2019年版IWGDF有关糖尿病足指南的学习心得（十）

糖尿病足的感染（下）：2019年版IWGDF有关糖尿病足指南的学习心得（九）

糖尿病足的感染（中）：2019年版IWGDF有关糖尿病足指南的学习心得（八）

糖尿病足的感染（上）：2019年版IWGDF有关糖尿病足指南的学习心得（七）

糖尿病外周血管病变诊疗（下）：2019年版IWGDF有关糖尿病足指南的学习心得（六）

糖尿病外周血管病变诊疗（中）：2019年版IWGDF有关糖尿病足指南的学习心得（五）

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Custom Mod Mega1

主任医师、教授、博导，南方医科大学第三附属医院（广东省骨科医院）院长

伤口世界

糖尿病足的感染：2019年版IWGDF有关糖尿病足指南的学习心得（十）

糖尿病足的感染（下）：2019年版IWGDF有关糖尿病足指南的学习心得（九）

糖尿病足的感染（中）：2019年版IWGDF有关糖尿病足指南的学习心得（八）

糖尿病足的感染（上）：2019年版IWGDF有关糖尿病足指南的学习心得（七）

糖尿病外周血管病变诊疗（下）：2019年版IWGDF有关糖尿病足指南的学习心得（六）

糖尿病外周血管病变诊疗（中）：2019年版IWGDF有关糖尿病足指南的学习心得（五）

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