Islam.I.Ragab1 Ahmed Kamal 2
1. Lecturer, Adult Medical Surgical Nursing Department, Faculty of Nursing, South Valley University, Qena, Egypt
2. Assistant Professor, Department of Plastic Surgery, Faculty of Medicine, Assiut University, Assiut Egypt
Abstract:
Introduction: Wound cleansing remains a corner stone in the management of diabetic foot ulcer. Hydrogen Peroxide (H2O2) and Povidone Iodine are topical antimicrobial agents but known to be toxic to cells involved in the wound healing cascade. The biggest challenge for the physicians and nurses is searching for a safe, non-cytotoxic and effective wound cleansing as Hypochlorous acid (HOCL). This study aimed to compare the efficacy of HOCL versus H2O2 followed by Povidine Iodine as a wound care agent in treating infected diabetic foot ulcers. Patients and methods: Design: used a randomized clinical trial design to compare the efficacy of HOCL versus H2O2 followed by Povidine Iodine as a wound care agent in treating infected diabetic foot ulcers.
Setting: This study was carried out in outpatient plastic and vascular surgery clinic at Assiut university Hospital.
Subjects: A random selection was performed on 60 patients with infected diabetic foot ulcers divided equally to control and study group. Methods: HOCL was used for the study group, as irrigate the wound with HOCL in a concentration; sterile Nacl 0.9% to HOCL 50.5% at ratio 8:2 and leave for 5 minutes, before covered the wound with sterile dressing. While H2O2 followed by Povidine Iodine used for the control group and the results were compared. Bacterial cultures were obtained before start washing, after five days thin each five days to the end of the study for the two groups.
Results: HOCL was able to be effective against Candida, Proteus, Klebsella, Psudomonas, and Methicillin resistant staphylococcus aureus (MARSA) compare to H2O2 and Povidine iodine. There is a statistically significant difference between using HOCL and H2O2 and Povidine iodine as a washing therapy in reducing bacterial count, wound pain, odor, discharge and improve wound healing in diabetic foot ulcer.
Conclusion: Hypochlorous acid is a potent antimicrobial cleanser against a wide range of microorganisms. Hypochlorous Acid is safe, low cost, painless, easy to perform, and improve wound healing or rapidly prepared diabetic foot ulcer for skin flap or graft. Recommendation: The study recommended use of HOCL as a virtuous diabetic wound care cleanser. Further research is needed on a larger scale to validate the effectiveness of Hypochlorous acid as a wound care agent in septic diabetic foot ulcers.
Keywords: Hypochlorous Acid, Hydrogen Peroxide, Infected diabetic foot ulcer, Povidine Iodine.
Azadeh Dorostkar1 , Mehdi Ghahartars1 , Mohammadreza Namazi1 , Nafiseh Todarbary2 , Maryam Hadibarhaghtalab1 , Maryam Rezaee1
1 Dermatology Department, Shahid Faghihi Hospital, Shiraz University of Medical Sciences, Shiraz, Iran
2 Student Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran
Key words: topical, sodium hypochlorite, acne vulgaris, treatment
Citation: Dorostkar A, Ghahartars M, Namazi M, Todarbary N, Hadibarhaghtalab M, Rezaee M. Sodium hypochlorite 0.005% versus placebo in the treatment of mild to moderate acne: a double-blind randomized controlled trial. Dermatol Pract Concept. 2021;11(3):e2021046. DOI: https://doi.org/10.5826/dpc.1103a46
Accepted: December 9, 2020; Published: May 20, 2021
Copyright: ©2021 Dorostkar et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License BY-NC-4.0, which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original authors and source are credited.
Competing interests: The authors have no conflicts of interest to declare.
Funding: None
Corresponding author: Maryam Hadibarhaghtalab, Department of Dermatology, Faghihi Hospital, Zand Street, Shiraz, Iran.
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ABSTRACT
Background: Acne vulgaris is a common inflammatory disease of the pilosebaceous follicle that affects many teenagers and young people. There is an obvious need for topical treatments with good tolerability and efficacy for the management of acne lesions.
Objective: This study determined the therapeutic efficacy of topical sodium hypochlorite solution (0.005%) in the treatment of mild to moderate acne lesions.
Methods: This placebo-controlled randomized controlled trial compared 0.005% sodium hypochlorite to placebo administered topically on each side of the patients’ faces 3 times a day for 1 month. The numbers of papules and pustules were recorded at baseline, 1, 2 and 4 weeks after initiation.
Results: The total number of papules and pustules decreased after topical application of sodium hypochlorite 0.005% for 1 month.
Conclusions: Topical sodium hypochlorite solution (0.005%) can be effective in the treatment of mild to moderate acne, and its clinical efficacy was evaluated between the male and female groups and between the hormonal and non-hormonal ones.
Trial registration: Our study was registered in the Iranian Registry of Clinical Trials (IRCT) with the code number IRCT20200701047976N1.
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佛山市禅城区中心医院慢性伤口造口专科主任。
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2019广东省医疗行业协会伤口管理分会年会
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