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03 9月 2019

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Author : 伤口世界

擅长造口护理、造口并发症处理，对外科术后感染伤口、肿瘤伤口、下肢动/静脉溃疡、失禁、瘘管、糖尿病溃疡足、放射性皮炎及其他慢性疑难伤口处理均具有丰富的经验。

国际造口/伤口失禁治疗师（ET），东莞康华医院普外科护士长，广东省护士协会第一届伤口造口失禁护士分会常委，广东省家庭医师协会护理分会第一届委员常务委员会委员，广东省家庭医生协会护理分会第一届委员，康华医院伤口/造口/失禁专科护理质量管理副组长。参与东莞市科技进步奖一等奖课题一项，主持及参与市级课题3项，发表科研论文4篇，2015年获广东省伤口造口PPT演讲比赛第一名，2017在东莞市护理学会举办“东莞市伤口护理病例大赛”中荣获优胜奖。东莞市伤口造口实习基地带教老师、

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Nicotinamide: A Multifaceted Molecule in Skin Health and Beyond 2025-04-10 00:00

Lara Camillo, Elisa Zavattaro and Paola Savoia *

Department of Health Science, Università del Piemonte Orientale, 28100 Novara, Italy;

该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。 (L.C.); 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。 (E.Z.)

* Correspondence: 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。; Tel.: +39-0321-373-3387

Academic Editor: Adam Reich

Received: 30 December 2024

Revised: 23 January 2025

Accepted: 27 January 2025

Published: 1 February 2025

Citation: Camillo, L.; Zavattaro, E.; Savoia, P. Nicotinamide: A

Multifaceted Molecule in Skin Health and Beyond. Medicina 2025, 61, 254.

https://doi.org/10.3390/ medicina61020254

Copyright: © 2025 by the authors. Published by MDPI on behalf of the Lithuanian University of Health Sciences. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/ licenses/by/4.0/)

Abstract: Nicotinamide (NAM), the amide form of vitamin B3, is a precursor to essential cofactors nicotinamide adenine dinucleotide (NAD+ ) and NADPH. NAD+ is integral to numerous cellular processes, including metabolism regulation, ATP production, mitochondrial respiration, reactive oxygen species (ROS) management, DNA repair, cellular senescence, and aging. NAM supplementation has demonstrated efficacy in restoring cellular energy, repairing DNA damage, and inhibiting inflammation by suppressing proinflammatory cytokines release. Due to its natural presence in a variety of foods and its excellent safety profile—even at high doses of up to 3 g/day—NAM is extensively used in the chemoprevention of non-melanoma skin cancers and the treatment of dermatological conditions such as blistering diseases, atopic dermatitis, rosacea, and acne vulgaris. Recently, its anti-aging properties have elevated NAM’s prominence in skincare formulations. Beyond DNA repair and energy replenishment, NAM significantly impacts oxidative stress reduction, cell cycle regulation, and apoptosis modulation. Despite these multifaceted benefits, the comprehensive molecular mechanisms underlying NAM’s actions remain not fully elucidated. This review consolidates recent research to shed light on these mechanisms, emphasizing the critical role of NAM in cellular health and its therapeutic potential. By enhancing our understanding, this work underscores the importance of continued exploration into NAM’s applications, aiming to inform future clinical practices and skincare

Keywords: nicotinamide; chemoprevention; skin health; cellular oxidative stress; DNA damage; photoaging; ultraviolet radiation; inflammation; vitamin B3
Acheta domesticus: A Natural Source of Anti-Skin-Aging Ingredients for Cosmetic Applications 2025-04-09 00:00

Kankanit Yeerong 1 , Panuwan Chantawannakul 2 , Songyot Anuchapreeda 3,4 , Thomas Rades 5 ,

Anette Müllertz 5,6 and Wantida Chaiyana 1,4,7,*

1 Department of Pharmaceutical Sciences, Faculty of Pharmacy, Chiang Mai University, Chiang Mai 50200, Thailand; 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。

2 Bee Protection Laboratory, Department of Biology, Faculty of Science, Chiang Mai University, Chiang Mai 50200, Thailand; 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。

3 Division of Clinical Microscopy, Department of Medical Technology, Faculty of Associated Medical Sciences, Chiang Mai University, Chiang Mai 50200, Thailand; 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。

4 Center of Excellence in Pharmaceutical Nanotechnology, Faculty of Pharmacy, Chiang Mai University, Chiang Mai 50200, Thailand

5 Department of Pharmacy, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, 2100 Copenhagen, Denmark; 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。 (T.R.); 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。 (A.M.)

6 Bioneer:FARMA, Department of Pharmacy, University of Copenhagen, Universitetsparken 2, 2100 Copenhagen, Denmark

7 Multidisciplinary and Interdisciplinary School, Chiang Mai University, Chiang Mai 50200, Thailand *

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Abstract: Acheta domesticus is an edible insect, rich in nutritional value and considered a sustainable protein source. This study aimed to investigate the potential application of A. domesticus extracts for anti-skin-aging purposes. The extracts were prepared by maceration at ambient temperature with 95% ethanol or hexane and maceration in gentle heat (45 ◦C) with 95% v/v ethanol or DI water. The extracts were examined for total protein, phenolic, and flavonoid contents. Protein molecular weight distribution was analyzed. The safety of the extracts was investigated in terms of irritation and cytotoxicity. Biological activities relevant to the inhibition of skin aging were evaluated, including increasing transforming growth factor-beta 1 (TGF-β1) expression and inhibitory activities on collagenase and hyaluronidase. The aqueous extract from maceration in gentle heat had the highest total protein content (63 ± 1% w/w), total phenolic content (0.48 ± 0.03 mg GAE/g extract), TGF-β1

stimulating activities (33 ± 2 pg/mL), and collagenase inhibition (with a half maximal inhibitory

concentration of 26 ± 1 µg/mL) among various extracts investigated. It caused no irritation to the

hen’s egg chorioallantoic membrane and showed no cytotoxicity to human dermal fibroblasts and

peripheral blood mononuclear cells. Therefore, aqueous A. domesticus extract is proposed as an

innovative natural anti-skin-aging ingredient.

Keywords: Acheta domesticus; anti-aging skincare; cosmetic; human dermal fibroblast; safety
Protective Effects of Sesame Glycoproteins on Ultraviolet-Induced Skin Aging: In Vitro and In Vivo Studies 2025-04-08 00:00

Kyung Kyu Baik 1,†, Woo-Yong Song 2,†, Dong Keun Song 1 , Jaehyeok Yun 1 , Ji Hwan Jang 1 , Jae Young Oh 1 , Mi-Jin Lee 2 , Eunjandi Go 2 , Kyong Jin Lee 2 , Eunmiri Roh 3 and Jong-Eun Kim 1,*

1 Department of Food Science and Technology, Korea National University of Transportation, Jeungpyeong 27909, Republic of Korea; 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。 (K.K.B.); 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。 (D.K.S.); 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。 (J.Y.); 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。 (J.H.J.); 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。 (J.Y.O.)

2 CNABIOTECH Co., Ltd., Cheongju-si 28106, Republic of Korea; 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。 (W.-Y.S.); 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。 (M.-J.L.); 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。 (E.G.); 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。 (K.J.L.)

3 Department of Cosmetic Science, Kwangju Women’s University, Gwangju 62396, Republic of Korea; 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。

* Correspondence: 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。; Tel.: +82-43-820-5245; Fax: +82-43-820-5240

† These authors contributed equally to this work

Abstract: Background/Objectives: Ultraviolet (UV) radiation is a primary factor in skin photoaging, leading to wrinkles, reduced elasticity, and pigmentation changes due to damage to cellular DNA, proteins, and lipids. Glycoproteins from sesame cake (SPE) have potential protective effects against UV-induced skin aging. This study investigated the anti-photoaging effects of SPE on UV-induced damage in human keratinocyte HaCaT cells and SKH-1 hairless mice. Methods: SPE was evaluated for its ability to mitigate UV-induced damage in HaCaT cells by assessing MMP-1 protein and mRNA expression levels, as well as the activity of transcription factors AP-1 and NF-κB. The phosphorylation of AKT and MAPK pathways was also analyzed. In vivo, SKH-1 hairless mice were exposed to UV radiation, and the effects of SPE on wrinkle formation and skin structure were assessed by measuring wrinkle length, area, and volume. Results: SPE significantly inhibited UV-induced MMP-1 protein and mRNA expression in HaCaT cells, indicating suppression of AP-1 and NF-κB transcription factors involved in MMP-1 production. Additionally, SPE reduced UV-induced phosphorylation of AKT and MAPK pathways. In SKH-1 hairless mice, SPE treatment led to significant reductions in wrinkle length, area, and volume, preserving skin structure in UV-exposed mice. Conclusions: The findings demonstrate that SPE has protective effects against UV-induced photoaging by inhibiting key molecular pathways associated with skin aging. SPE shows promise as a natural anti-photoaging agent, providing a foundation for future skincare product development. Further studies are warranted to explore the molecular mechanisms in detail and to validate these effects through clinical trials.

Keywords: sesame glycoproteins; ultraviolet; skin; aging

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