Boost of cosmetic active ingredient penetration triggered and controlled by the delivery of kHz plasma jet on human skin explants

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24 12月 2025

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Author : 伤口世界

Boost of cosmetic active ingredient penetration triggered and controlled by the delivery of kHz plasma jet on human skin explants

This article is excerpted from the 《Frontiers in Physics》 by Wound World

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伤口世界

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Irrigation Solutions in Wound Care and Breast Surgery: Evidence-Based Applications, Regulatory Considerations, and Future Directions 2026-08-17 00:00

Stephanie M. Mueller ^1,2, LaYow C. Yu ², Michael Drake Pike ², Hannah D. Shi ² and Dennis P. Orgill ^1,2,*

1 Division of Plastic and Reconstructive Surgery, Brigham and Women’s Hospital, 75 Francis St, Boston, MA 02115, USA; 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。

2 Harvard Medical School, 25 Shattuck St, Boston, MA 02115, USA; 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。 (L.C.Y.); 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。 (M.D.P.); 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。 (H.D.S.)

* Correspondence: 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。

Abstract

Background: Irrigation is a key strategy in reducing bioburden, disrupting biofilms, and supporting wound healing. While saline is the standard for its safety and availability, antiseptic and antibiotic solutions are often used in clinical scenarios that require infection control. However, the rise in antibiotic stewardship and concerns regarding cytotoxicity are reshaping current practices. This review identifies recent trends, current controversies, and persistent gaps in knowledge that warrant further investigation and regulatory attention. Methods: A literature review identified irrigation solutions commonly used in plastic surgery; labeling and concentrations were obtained from Devices@FDA, Drugs@FDA, and DailyMed, and PubMed, Cochrane Central, and Embase were searched (January 2022–July 2025) for human studies on acute wounds, chronic wounds, and implant-based breast surgery. Results: In acute wounds, saline and potable tap water effectively prevent infection. In chronic wounds, such as diabetic foot ulcers and pressure injuries, antiseptic agents, including hypochlorous acid, sodium hypochlorite, polyhexanide, and citrate-based solutions, have shown promise in improving healing and reducing infection. In implant-based breast reconstruction and augmentation, data on antiseptics, such as chlorhexidine, and changes in FDA guidance for povidone–iodine and bacitracin have prompted a reevaluation of intraoperative irrigation practices. Conclusion: Despite widespread use, many antiseptics remain off-label, and high-quality clinical studies comparing efficacy and safety are lacking.

Keywords: wound irrigation; saline irrigation; antiseptic irrigation; surgical site infection/prevention and control; breast pocket irrigation; Povidone–Iodine (PVI); Polyhexamethylene Biguanide/polyhexanide (PHMB); Hypochlorous Acid (HOCl); Sodium Hypochlorite (NaOCl); Triple antibiotic solution (TAS)
Phenotypic Switching Resulting From Developmental Plasticity: Fixed or Reversible? 2026-08-15 00:00

Warren W. Burggren*

Developmental Integrative Biology, Department of Biological Sciences, University of North Texas, Denton, TX, United States
Fusobacterium nucleatum: More Than Just an Oral Anaerobe 2026-08-14 00:00

Akash Patel , Monica Patel , Joseph Glowacki

1.Internal Medicine, St. Mary Medical Center, Langhorne , USA 2. Internal Medicine, Temple University Hospital, Philadelphia, USA 3. Internal Medicine, Rowan University School of Medicine, Stratford, USA

Corresponding author: Akash Patel, 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。

Abstract

Fusobacterium nucleatum is a strict anaerobe that is indigenous to the human oral cavity, where it coexists with more than 500 other species. It is associated with paranasal sinus, odontogenic, and pulmonary infections. In literature, cases of Fusobacterium nucleatum are rare. Here we report a case of a patient with multiple brain abscesses caused by Fusobacterium nucleatum. This case report looks to assist clinicians in determining the true etiology of this organism, which can change patient management based on the current literature review and similar case studies.

Categories: Internal Medicine, Infectious Disease, Neurosurgery

Keywords: anaerobes of clinical importance, colon cancer surveillance, periodontal disease, brain abscess, fusobacterium nucelatum

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主任医师、教授、博导，南方医科大学第三附属医院（广东省骨科医院）院长

Boost of cosmetic active ingredient penetration triggered and controlled by the delivery of kHz plasma jet on human skin explants

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主任医师、教授、博导，南方医科大学第三附属医院（广东省骨科医院）院长

Boost of cosmetic active ingredient penetration triggered and controlled by the delivery of kHz plasma jet on human skin explants

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