李孝建

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26 8月 2019

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Author : 伤口世界

专长：重症烧伤救治。广东省医学会烧伤科分会主任委员、广东省医疗行业协会伤口管理分会副主委。

广东红十字会医院烧伤整形科主任医师，博士研究生导师。烧伤科大主任、烧伤ICU主任。

Latest from 伤口世界

０.０１％次氯酸在白内障超声乳化术前应用的安全性和有效性
ADJUNCTIVE DEBRIDEMENT WITH HYPOCHLOROUS ACID LEADS TO A HEALING TRAJECTORY OF COMPLEX WOUNDS IN CHILDREN
Hypochlorous Acid (HOCl) as a Promising Respiratory Antiseptic
Comparison of Skin Antiseptic Agents and the Role of 0.01% Hypochlorous Acid
The Potential Use of Hypochlorous Acid and a Smart Prefabricated Sanitising Chamber to Reduce Occupation-Related COVID-19 Exposure

K2 Content

０.０１％次氯酸在白内障超声乳化术前应用的安全性和有效性 2026-08-24 00:00

王雨蒙，陆秋辰，赵颖奕，史灿灿，李明新，王贺
ADJUNCTIVE DEBRIDEMENT WITH HYPOCHLOROUS ACID LEADS TO A HEALING TRAJECTORY OF COMPLEX WOUNDS IN CHILDREN 2026-08-22 00:00

Ferne T. Elsass, MSN, RN, CPN, CWON; Clinical Practice and Education Specialist of Wound and Ostomy, Children’s Hospital of The King’s Daughters, Norfolk, VA 23507
Hypochlorous Acid (HOCl) as a Promising Respiratory Antiseptic 2026-08-21 00:00

Michael Winter ¹, Dirk Boecker ²and Wilfried Posch ^3,*

1 Team Winter Kompetenztraining, 1030 Vienna, Austria; 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。

2 TOTO Consulting LLC, Campbell, CA 95080, USA; 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。

3 Institute of Hygiene and Medical Microbiology, Medical University of Innsbruck, Schöpfstrasse 41/R311,6020 Innsbruck, Austria

*Correspondence: 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。; Tel.: +43-512-9003-70706

Abstract

The COVID-19 pandemic has inflicted unprecedented pressure on communities and health-care systems around the world. An outstandingly broad and intensive investigation of possible therapeutic interventions is currently taking place to prevent similar future threats to the global population. Investigating the related mechanisms of action is often complex and time consuming. Moreover, research on biochemical interactions of new drugs involves a considerable amount of effort, consequently bearing inherent financial and operational risks for pharmaceutical companies. An interesting approach to counteract colonization and infection is the concept of antiseptic treatment in vivo. Antiseptics are cost-effective and globally accessible, due to their ease of production, transportation and handling. A broad spectrum of active agents with different properties is readily available. One of these substances is hypochlorous acid (HOCl), which is also a naturally occurring biocidal agent and as such part of the innate immune system. Its successful history of medical use in wound treatment, combined with low cytotoxicity and documented efficacy against various pathogens, suggests that HOCl might be an effective agent for treating the respiratory mucosa. This could potentially enable therapeutic inhalation for combating bacterial infections and viral pathogens such as human respiratory syncytial, influenza, and SARS-CoV-2 viruses, which will be discussed in the present article.

Keywords: HOCl; respiratory infection; antiseptic; antimicrobial treatment; RSV; influenza; COVID-19; SARS-CoV-2

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主任医师、教授、博导，南方医科大学第三附属医院（广东省骨科医院）院长

李孝建

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主任医师、教授、博导，南方医科大学第三附属医院（广东省骨科医院）院长

李孝建

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